J Pathol Transl Med.  2020 Sep;54(5):426-431. 10.4132/jptm.2020.06.18.

Renal intravascular large B cell lymphoma: the first case report in Korea and a review of the literature

Affiliations
  • 1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
  • 2Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

Abstract

Herein, we describe the first case of renal intravascular large B cell lymphoma in Korea occurring in a 66-year-old female. She presented with mild fever and dyspnea. On physical and laboratory evaluations, hemophagocytic lymphohistiocytosis was suspected, but the bone marrow biopsy results were unremarkable. During the work-up, massive proteinuria developed, which led to a renal biopsy. The renal architecture was relatively well-preserved, but the glomeruli were hypercellular with the infiltration of atypical, large lymphoid cells with increased nucleus-cytoplasm ratio and clumped chromatin. Similar cells were also present in the peritubular capillaries. The tumor cells exhibited membranous staining for CD20 and CD79a. After the diagnosis of intravascular large B cell lymphoma, the patient received rituximab-based chemotherapy under close follow-up.

Keyword

Intravascular large B cell lymphoma; Kidney glomerulus; Peritubular capillary
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