J Korean Orthop Assoc.  2020 Aug;55(4):331-337. 10.4055/jkoa.2020.55.4.331.

Prognostic Indicators of Extremity Liposarcoma

Affiliations
  • 1Departments of Orthopedic Surgery, *Radiology, and †Pathology, Pusan National University School of Medicine, Yangsan, Korea

Abstract

Purpose
The aim of this retrospective study was to define the prognostic factors for liposarcoma to aid in the selection of effectivetreatments.
Materials and Methods
This study analyzed 41 cases out of 45 cases diagnosed with and treated for liposarcoma 2002 to 2015; 4 casesof well-differentiated liposarcoma were excluded. The effects of sex, age, site, stage, and histological classification on survival wereanalyzed retrospectively. For 28 cases diagnosed with myxoid liposarcoma, additional analysis was performed after the inclusion of roundcell components.
Results
The mean age at diagnosis was 52.05 years (range 25–82 years) and the average follow-up period was 63.7 months. The diseasefreesurvival rate was 43.2%. Most factors, including sex and age, were not significantly associated with the survival rate. On the otherhand, the stage (Musculoskeletal Tumor Society stage) was significantly associated with the survival rate. The survival rate of patients withmyxoid liposarcoma was 69% and the local recurrence and metastasis results varied according to the presence of round cells.
Conclusion
The stage of liposarcoma and the sex of the patient were found to be effective factors for prognosis. When planning thetreatment for liposarcoma, the treatment outcome for liposarcoma differs according to several prognostic factors.

Keyword

liposarcoma; myxoid liposarcoma; round cell liposarcoma
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