J Korean Bone Joint Tumor Soc.  2010 Dec;16(2):62-68. 10.5292/jkbjts.2010.16.2.62.

Liposarcoma in the Extremity

• Lee SH
• Cho IJ
• Yang WI
• Suh JS
• Shin KH

• KMID: 1456319
• DOI: http://doi.org/10.5292/jkbjts.2010.16.2.62

Abstract

PURPOSE
We analyzed disease free survival and the prognostic factors of liposarcoma in the extremity.
MATERIALS AND METHODS
Between 1994 and 2005, of 44 patients who were diagnosed and treated for liposarcoma of the extremity, 40 patients were restrospectively analysed. 13 out of 40 patients got postoperative radiotherapy. We examined local recurrence, distant metastasis and disease free 5-year survival rate. We also analyzed clinical prognostic factors, such as age, gender, size of tumor, prior unplanned excision, histologic type, surgical excision margin and postoperative radiotherapy respectively.
RESULTS
There were 3 cases of local recurrence and 4 cases of distant metastasis. The disease free 5-year survival rate was 85.0%. 26 patients presented with myxoid, 8 well differentiated, 4 round cell, 1 pleomorphic and 1 dedifferentiated histology. The disease free 5-year survival rate of mixoid, well differentiated and round cell liposarcoma were 100.0%, 84.6% and 75.0% (p=0.419). The 5-year disease free survival rate was 90.6% in negative surgical margin (n=25) and 62.5% in positive surgical margin (n=15) (p=0.003).
CONCLUSION
Our study suggests that surgical excision margin is significant prognostic factor for 5-year disease free survival rate.

Keyword

extremity; liposarcoma; disease free 5-year survival rate; prognostic factor

MeSH Terms

Disease-Free Survival
Extremities
Humans
Liposarcoma
Neoplasm Metastasis
Recurrence
Survival Rate

Figure

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  Figure 1. The round cell liposarcoma was diagnosed in the right thigh of 24 year old male patient. (A) T1-weighted axial MR image. (B) T2-weighted fat suppressed axial MR image. (C, D) Gross photos of liposarcoma. (E) Cross section of liposarcoma.

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  Figure 2. The graph shows the cumulative disease free survival of patients of liposarcoma in extremities. The 5-year disease free survival rate was 85.0%.

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  Figure 3. The graph shows disease free survival curve according to histological type of liposarcoma. The 5-year disease free survival rate of well-differentiated liposarcoma, mixoid liposarcoma and round cell liposarcoma were 100%, 84.6% and 75.0% respectively. The p-value was 0.419 in the log rank test.

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  Figure 4. The graph shows disease free survival curve according to surgical margin. The 5-year disease free survival rate of the negative margin was 90.6% and that of the positive margin was 62.5%. The p-value was 0.003 in the log rank test.

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