J Korean Med Sci.  2020 Aug;35(34):e296. 10.3346/jkms.2020.35.e296.

Association of Self-Reported and Cotinine-Verified Smoking Status with Atrial Arrhythmia

• Lee SH
• Kim BJ
• Kang J
• Seo DC
• Lee SJ

• KMID: 2505724
• DOI: http://doi.org/10.3346/jkms.2020.35.e296

Abstract

Background
The relationship between self-reported and urinary cotinine-verified smoking status and atrial arrhythmia (AA) is unclear. The aim of this study was to evaluate the association of self-reported and urine cotinine-verified smoking status with AA. Method: A total of 201,788 participants (106,375 men, mean age 37 years) who had both a urinary cotinine measurement and electrocardiogram were included. Cotinine-verified current smoking was defined as a urinary cotinine level above 50 ng/mL. Individuals were divided into three groups based on self-reported smoking and two groups based on cotinineverified smoking status.
Results
Among overall subjects, 505 had documented AA (0.3%) and 135 had atrial fibrillation (AF) (0.1%). Self-reported current smoking was associated with an increased risk of AA (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.06–1.91; p = 0.019) and AF (OR, 2.20; 95% CI, 1.24–3.90; p = 0.007), whereas self-reported former smoking had no significant association with AA (OR, 1.30; 95% CI, 0.97–1.73; p = 0.078) and AF (OR, 1.74; 95% CI, 1.00–3.04; p = 0.051). Cotinine-verified current smoking showed no significant association with AA (OR, 1.24; 95% CI, 0.98–1.58; p = 0.080) and AF (OR, 1.20; 95% CI, 0.79–1.83; p = 0.391).
Conclusion
Self-reported current smoking was associated with AA and AF, while selfreported former smoking and cotinine-verified current smoking showed no significant association with AA and AF.

Keyword

Cigarette Smoking; Arrhythmias; Cotinine; Nicotine

Figure

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  Fig. 1 Multivariate regression analyses for the association between cotinine quartiles and AA.Multivariate logistic regression analyses showed that the OR for AA tend to increase linearly as the cotinine quartiles increased (P for trend, P = 0.046).AA = atrial arrhythmia, OR = odds ratio, CI = confidence interval.

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