Clin Exp Otorhinolaryngol.  2020 Aug;13(3):308-311. 10.21053/ceo.2019.02005.

Sneezing and Rubbing Counts in Allergic Rhinitis Mouse Models Are a Reliable Indicator of Type 2 Immune Response

• Ryu G
• Bae JS
• Kim JH
• Kim EH
• Chung YJ
• Mo JH

• KMID: 2504927
• DOI: http://doi.org/10.21053/ceo.2019.02005

Figure

• 

  Fig. 1. Sneezing and rubbing counts. (A) Sneezing and rubbing counts were significantly higher in the positive control group than in the negative control group. (B) Sneezing and rubbing counts at 5-minute intervals. The average count from the first 5-minute interval was higher than that of the consecutive 5-minute intervals. (C) Eosinophil count was significantly higher in the positive control group. ***P<0.001.

• 

  Fig. 2. Correlation analysis between sneezing and rubbing counts and type 2 allergic parameters. (A) Type 2 immune response mediators were closely correlated with sneezing and rubbing counts for 0–20 minutes (P<0.001). (B) Summary of correlation coefficients according to the time interval. The correlation coefficient of nasal IL-4 mRNA levels was the highest among the type 2 markers. IgE, immunoglobulin E; OVA, ovalbumin; OD, optical density; IL, interleukin.

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