Korean J Otorhinolaryngol-Head Neck Surg.
2012 Oct;55(10):609-615. 10.3342/kjorl-hns.2012.55.10.609.
Allergic Rhinitis Mouse Model
- Affiliations
-
- 1Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University Hospital, College of Medicine, Hanyang University, Seoul, Korea. shcho@hanyang.ac.kr
- KMID: 1493619
- DOI: http://doi.org/10.3342/kjorl-hns.2012.55.10.609
Abstract
- Allergic rhinitis is the most common atopic disease in the world. However, pathogenic mechanisms of allergic rhinitis have not been fully understood. Mouse models of allergic rhinitis are a great tool that allows in vivo studies to be conducted in the state of an intact immune and respiratory system. This model system can provide many chances to find important signaling pathways and therapeutic target molecules in allergic rhinitis. To start research in allergic rhinitis with mouse, we have to make good and reliable models. Current mouse model is not perfect with many confounding variables and has some limitations to translate findings to the clinic directly. Optimal mouse model mimicking human allergic rhinitis will promise to unravel new horizon in the field of allergic rhinitis.
