J Obes Metab Syndr.  2020 Mar;29(1):47-57. 10.7570/jomes19055.

The Effect of Curcumin Supplementation and AerobicTraining on Anthropometric Indices, Serum LipidProfiles, C-Reactive Protein and Insulin Resistance inOverweight Women: A Randomized, Double-Blind,Placebo-Controlled Trial

Affiliations
  • 1Department of Nutrition, Ministry of Health, Tehran, Iran
  • 2Department of Health Tehran University of Medical Sciences, Tehran, Iran
  • 3Department of Exercise Physiology, Faculty of Physical Education, Islamic Azad University of Tehran, Tehran, Iran
  • 4Nutrition Group, Abadan School of Medical Sciences, Abadan, Iran
  • 5Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Islamic Azad University, Central Tehran Branch, Tehran, Iran

Abstract

Background
This study aimed to investigate the effects of curcumin supplementation alone and in combination with aerobic training on body composition, glycemic variables, serum levels of C-reactive protein (CRP) andlipid profiles in overweight women.
Methods
In this randomized, double-blind, placebo-controlled trial, 40 healthy sedentary overweight females(aged 30–45 years with body mass index [BMI] of 25–30 kg/m2) were randomly assigned to four groups of 10subjects each: curcumin supplementation (Cur), placebo (Pla), placebo+aerobic training (Pla+Tra), curcuminsupplementation+aerobic training (Cur+Tra). Curcumin or placebo capsules (500 mg/day) were administeredfor 8 weeks.
Results
During the intervention, Cur group showed significant reductions in weight, BMI and fasting bloodglucose level; Cur+Tra group decreased waist circumference, waist-to-hip ratio, homeostatic model assessmentfor insulin resistance, serum insulin level, low-density lipoprotein to high-density lipoprotein ratio, and totalcholesterol to high-density lipoprotein ratio and increased serum high-density lipoprotein cholesterol. The between-groups analysis indicated increased high-density lipoprotein cholesterol in the Cur and Cur+Tra groupscompared to the Pla group. The estimated marginal means of serum CRP were significantly higher in Pla+Tragroup than in the Cur and Cur+Tra groups.
Conclusion
These findings suggest that the combination of curcumin supplementation with aerobic trainingmore effectively improves glycemic and lipidemic statuses than curcumin supplementation or aerobic trainingalone.

Keyword

Curcumin; Exercise; Overweight; C-reactive protein; Lipids; Insulin resistance
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