J Obes Metab Syndr.  2020 Mar;29(1):47-57. 10.7570/jomes19055.

The Effect of Curcumin Supplementation and AerobicTraining on Anthropometric Indices, Serum LipidProfiles, C-Reactive Protein and Insulin Resistance inOverweight Women: A Randomized, Double-Blind,Placebo-Controlled Trial

• Dolati S
• Namiranian K
• Amerian R
• Mansouri S
• Arshadi S
• Azarbayjani MA

• KMID: 2504852
• DOI: http://doi.org/10.7570/jomes19055

Abstract

Background
This study aimed to investigate the effects of curcumin supplementation alone and in combination with aerobic training on body composition, glycemic variables, serum levels of C-reactive protein (CRP) andlipid profiles in overweight women.
Methods
In this randomized, double-blind, placebo-controlled trial, 40 healthy sedentary overweight females(aged 30–45 years with body mass index [BMI] of 25–30 kg/m²) were randomly assigned to four groups of 10subjects each: curcumin supplementation (Cur), placebo (Pla), placebo+aerobic training (Pla+Tra), curcuminsupplementation+aerobic training (Cur+Tra). Curcumin or placebo capsules (500 mg/day) were administeredfor 8 weeks.
Results
During the intervention, Cur group showed significant reductions in weight, BMI and fasting bloodglucose level; Cur+Tra group decreased waist circumference, waist-to-hip ratio, homeostatic model assessmentfor insulin resistance, serum insulin level, low-density lipoprotein to high-density lipoprotein ratio, and totalcholesterol to high-density lipoprotein ratio and increased serum high-density lipoprotein cholesterol. The between-groups analysis indicated increased high-density lipoprotein cholesterol in the Cur and Cur+Tra groupscompared to the Pla group. The estimated marginal means of serum CRP were significantly higher in Pla+Tragroup than in the Cur and Cur+Tra groups.
Conclusion
These findings suggest that the combination of curcumin supplementation with aerobic trainingmore effectively improves glycemic and lipidemic statuses than curcumin supplementation or aerobic trainingalone.

Keyword

Curcumin; Exercise; Overweight; C-reactive protein; Lipids; Insulin resistance