Immune Netw.  2020 Jun;20(3):e20. 10.4110/in.2020.20.e20.

The Roles of CCR7 for the Homing of Memory CD8+ T Cells into Their Survival Niches

• Choi H
• Song H
• Jung YW

• KMID: 2504714
• DOI: http://doi.org/10.4110/in.2020.20.e20

Abstract

Memory CD8+ T cells in the immune system are responsible for the removal of external Ags for a long period of time to protect against re-infection. Naïve to memory CD8+ T cell differentiation and memory CD8+ T cell maintenance require many different factors including local environmental factors. Thus, it has been suggested that the migration of memory CD8+ T cells into specific microenvironments alters their longevity and functions. In this review, we have summarized the subsets of memory CD8+ T cells based on their migratory capacities and described the niche hypothesis for their survival. In addition, the basic roles of CCR7 in conjunction with the migration of memory CD8+ T cells and recent understandings of their survival niches have been introduced. Finally, the applications of altering CCR7 signaling have been discussed.

Keyword

CD8-positive T-lymphocytes; Immunologic memory; Receptors, CCR7; Cell movement; Chemotaxis; Immunotherapy