J Korean Neurosurg Soc.  2020 Jul;63(4):463-469. 10.3340/jkns.2019.0179.

Expression and Significance of MicroRNA155 in Serum of Patients with Cerebral Small Vessel Disease

Affiliations
  • 1Department of Neurology, Pu’er People’s Hospital, Pu’er, China
  • 2Department of Internal Medicine, Pu’er City Prison Hospital, Pu’er, China

Abstract


Objective
: This study aimed to investigate the changes and significance of microRNA155 levels in serum of patients with cerebral small vessel disease (CSVD).
Methods
: Thirty patients with CSVD who met the inclusion criteria were selected and divided into eight patients with lacunar infarction (LI) group and 22 patients with multiple lacunar infarction (MLI) combined with white matter lesions (WML) group according to the results of head magnetic resonance imaging (MRI). Thirty samples from healthy volunteers without abnormalities after head MRI examination were selected as the control group. The levels of serum microRNA155 in each group were determined by real-time polymerase chain reaction, and the correlation between microRNA155 in the serum of patients with CSVD and the increase of imaging lesions was analyzed by Spearman correlation analysis.
Results
: Compared with the control group, the serum microRNA155 level in the LI group, MLI combined with WML group increased, the difference was statistically significant (p<0.05); serum microRNA155 level was positively correlated with the increase of imaging lesions (p<0.05).
Conclusion
: The change of serum microRNA155 level in patients with CSVD may be one of its self-protection mechanisms, and the intensity of this self-protection mechanism is positively correlated with the number of CSVD lesions.

Keyword

Cerebral small vessel disease; Serum; microRNA155 level; Real-time polymerase chain reaction; Self protection mechanism.
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