Korean J Gastroenterol.  2020 Jul;76(1):49-51. 10.4166/kjg.2020.76.1.49.

Regression of a Large Hyperplastic Polyp after Helicobacter pylori Eradication Treatment

• Kang SJ
• Shin CM

• KMID: 2504595
• DOI: http://doi.org/10.4166/kjg.2020.76.1.49

Figure

• 

  Fig. 1 Endoscopic treatment of gastric adenoma. (A) A 2.5 cm sized slightly depressed lesion with marginal elevation (type 0-IIc+IIa) was observed at the posterior wall of the antrum. (B) An endoscopic mucosal dissection was performed for the lesion. The final pathologic diagnosis was a 2.2×1.3 cm-sized tubular adenoma, low-grade dysplasia. The resection margin was negative for the tumor.

• 

  Fig. 2 Long-term follow-up of the hyperplastic polyp. Endoscopic surveillance was performed annually or biennially after the endoscopic treatment. Two years after the endoscopic treatment, a 2 cm sized hyperplastic polyp was noted on the endoscopic resection scar (A). There was no change in size 4, 6, and 8 years (B-D, respectively) after the endoscopic treatment. Nine years after the endoscopic treatment, nodularity was observed at the neck of the polyp. Thus, a biopsy was done to rule out malignancy (E). The pathologic diagnosis was Helicobacter pylori (H. pylori)-associated chronic active gastritis. (F) One year after the H. pylori eradication. The hyperemic polyp disappeared, and only its neck portion remained.

Reference

1. Stolte M, Sticht T, Eidt S, Ebert D, Finkenzeller G. 1994; Frequency, location, and age and sex distribution of various types of gastric polyp. Endoscopy. 26:659–665. DOI: 10.1055/s-2007-1009061. PMID: 7859674.

2. Shaib YH, Rugge M, Graham DY, Genta RM. 2013; Management of gastric polyps: an endoscopy-based approach. Clin Gastroenterol Hepatol. 11:1374–1384. DOI: 10.1016/j.cgh.2013.03.019. PMID: 23583466. PMCID: PMC3962745.

3. Goddard AF, Badreldin R, Pritchard DM, Walker MM, Warren B. British Society of Gastroenterology. 2010; The management of gastric polyps. Gut. 59:1270–1276. DOI: 10.1136/gut.2009.182089. PMID: 20675692.

4. Ji F, Wang ZW, Ning JW, Wang QY, Chen JY, Li Y. 2006; Effect of drug treatment on hyperplastic gastric polyps infected with Helicobacter pylori: a randomized, controlled trial. World J Gastroenterol. 12:1770–1773. DOI: 10.3748/wjg.v12.i11.1770. PMID: 16586550. PMCID: PMC4124356.

5. Nam SY, Park BJ, Ryu KH, Nam JH. 2016; Effect of Helicobacter pylori infection and its eradication on the fate of gastric polyps. Eur J Gastroenterol Hepatol. 28:449–454. DOI: 10.1097/MEG.0000000000000553. PMID: 26735158.

6. Asaka M, Kato M, Takahashi S, et al. 2010; Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition. Helicobacter. 15:1–20. DOI: 10.1111/j.1523-5378.2009.00738.x. PMID: 20302585.

7. Nam SY, Park BJ, Ryu KH, Nam JH. 2018; Effect of Helicobacter pylori eradication on the regression of gastric polyps in National Cancer Screening Program. Korean J Intern Med. 33:506–511. DOI: 10.3904/kjim.2016.286. PMID: 29232943. PMCID: PMC5943657.

8. Lim SA, Yun JW, Yoon D, et al. 2011; Regression of hyperplastic gastric polyp after Helicobacter pylori eradication. Korean J Gastrointest Endosc. 42:74–82.

9. Kang KH, Hwang SH, Kim D, et al. 2018; The effect of Helicobacter pylori infection on recurrence of gastric hyperplastic polyp after endoscopic removal. Korean J Gastroenterol. 71:213–218. DOI: 10.4166/kjg.2018.71.4.213. PMID: 29684970.

10. Nam SY, Lee SW, Jeon SW, Kwon YH, Lee HS. Helicobacter pylori eradication regressed gastric hyperplastic polyp: a randomized controlled trial. Dig Dis Sci. 2020 Jan 23. [Epub ahead of print]. DOI: 10.1007/s10620-020-06065-0.