Korean J Gastroenterol.  2018 Apr;71(4):213-218. 10.4166/kjg.2018.71.4.213.

The Effect of Helicobacter pylori Infection on Recurrence of Gastric Hyperplastic Polyp after Endoscopic Removal

• Kang KH
• Hwang SH
• Kim D
• Kim DH
• Kim SY
• Hyun JJ
• Jung SW
• Koo JS
• Jung YK
• Yim HJ
• Lee SW

• KMID: 2409890
• DOI: http://doi.org/10.4166/kjg.2018.71.4.213

Abstract

BACKGROUND/AIMS
Several previous studies suggest that eradication of Helicobacter pylori (H. pylori) leads to the disappearance of gastric hyperplastic polyps. However, little is known about the effect of H. pylori status and eradication on the recurrence of gastric polyps after endoscopic removal. Here, we investigated the recurrence of gastric polyps according to the final H. pylori status in patients who underwent endoscopic removal of gastric hyperplastic polyps.
METHODS
Between January 2011 and December 2016, patients who underwent endoscopic removal of gastric hyperplastic polyps and were followed-up for more than two months were enrolled. The success of H. pylori eradication was assessed by histology and rapid urease test or urea breath test, at least 4 weeks after the completion of eradication treatment. At follow-up, the recurrence of gastric polyp was evaluated via esophagogastroduodenoscopy.
RESULTS
Seventy-nine patients were enrolled. During the mean follow-up period of 16.4 months, the recurrence rate of gastric polyp was 25.3%. Among those who received H. pylori eradication therapy, the H. pylori persistent group showed a higher recurrence of polyp than the H. pylori eradicated group; but there was no statistical significance (42.9% vs. 21.7%, p=0.269). Regarding the final H. pylori infection status, the recurrence rate of gastric polyps was significantly higher in the H. pylori positive group than in the H. pylori negative group (42.9% vs. 18.9%, p=0.031). In multivariate analysis, the final H. pylori infection status was a significant risk factor for gastric polyp recurrence after endoscopic removal.
CONCLUSIONS
The final positive H. pylori infection status is significantly associated with higher recurrence of gastric hyperplastic polyps after endoscopic removal.

Keyword

Stomach neoplasms; Helicobacter pylori; Therapeutics; Recurrence

MeSH Terms

Breath Tests
Endoscopy, Digestive System
Follow-Up Studies
Helicobacter pylori*
Helicobacter*
Humans
Multivariate Analysis
Polyps*
Recurrence*
Risk Factors
Stomach Neoplasms
Urea
Urease
Urea
Urease

Figure

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  Fig. 1. Flow chart of this study. H. pylori, Helicobacter pylori; HP, Helicobacter pylori.

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  Fig. 2. Comparison of gastric hyperplastic polyp recurrence according to HP eradication status (HP eradicated vs. HP persistent). HP, Helicobacter pylori.

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  Fig. 3. Comparison of gastric hyperplastic polyp recurrence according to final HP status (HP negative status vs. HP positive status). HP, Helicobacter pylori.

Reference

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