Korean J Helicobacter Up Gastrointest Res.  2019 Dec;19(4):236-244. 10.7704/kjhugr.2019.0004.

Change in Size of Gastric Hyperplastic Polyps after Helicobacter pylori Eradication: A Prospective Study

• Yoo AY
• Park JJ
• Joo MK
• Lee BJ
• Chun HJ
• Lee SW

• KMID: 2469315
• DOI: http://doi.org/10.7704/kjhugr.2019.0004

Abstract

BACKGROUND/AIMS
Helicobacter pylori (H. pylori) eradication is known to be effective for reducing the size of gastric hyperplastic polyps (HPPs). This study investigated the change in size of gastric HPPs after H. pylori eradication.
MATERIALS AND METHODS
This was a prospective study that enrolled 25 H. pylori-positive patients diagnosed as having HPPs at Korea University Guro Hospital between July 2015 and July 2016. If the patient wanted to receive eradication therapy, medication was given. If the patients refused eradication, only clinical follow-up was performed. All patients were subsequently followed up with endoscopic examination to determine any change in polyp size.
RESULTS
Eighteen of the 25 H. pylori-positive patients diagnosed as having HPPs were given an eradication regimen, and 17 were confirmed to have achieved successful eradication. Twelve (70.8%) of the 17 patients in the eradication group showed ≥50% reduction in size, while two (25.0%) of the eight patients in the non-eradication group showed 50% reduction. The polyp regression rate was significantly higher in the eradication group (P=0.03). A multivariate analysis revealed that H. pylori eradication (OR, 40.047; 95% CI, 1.112~1442.767; P=0.044) and female sex (OR, 12.947; 95% CI, 1.038~161.503; P=0.047) were significant predictive factors of HPP regression.
CONCLUSIONS
H. pylori eradication is an effective therapeutic modality for gastric HPP regression.

Keyword

Helicobacter pylori; Polyps; Stomach neoplasms

MeSH Terms

Female
Follow-Up Studies
Helicobacter pylori*
Helicobacter*
Humans
Korea
Multivariate Analysis
Polyps*
Prospective Studies*
Stomach Neoplasms