Lab Med Online.  2020 Jul;10(3):202-206. 10.3343/lmo.2020.10.3.202.

Performance Evaluation of the ABL90 FLEX PLUS Point-of-Care Analyzer in Measuring Creatinine Levels

• Lee S
• Ahn HJ
• Yoo J

• KMID: 2504129
• DOI: http://doi.org/10.3343/lmo.2020.10.3.202

Abstract

Background
To diagnose acute renal failure, creatinine levels in whole blood are typically assessed using point-of-care testing (POCT) methods. The present study aimed to evaluate the performance of a newly developed POCT blood gas analyzer, the ABL90 FLEX PLUS (Radiometer, Denmark), which can measure creatinine in blood.
Methods
Precision and linearity of the ABL90 FLEX PLUS were evaluated and compared with those of the Beckman Coulter AU5800 (Beckman Coulter, USA), according to the CLSI guidelines for creatinine measurement performance.
Results
For the ABL90 FLEX PLUS, the total imprecision (%CV) levels of two control materials were measured to be 0.0% and 0.8%, while linearity was evaluated, with the R2 value measured to be 0.9993 (0.4-8.4 mg/dL). Compared to the AU5800, the ABL90 FLEX PLUS correlation coefficient (r) was found to be 0.989. The 95% limits of agreement were determined to be -0.649 and 0.643 mg/dL (-18.8% and 17.8%).
Conclusions
The ABL90 FLEX PLUS exhibited good performance for creatinine test. This indicates that the ABL90 FLEX PLUS can be potentially useful in clinical laboratories.

Keyword

Creatinine; ABL90 FLEX PLUS; Point-of-care testing; Kidney function tests

Figure

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  Fig. 1 Linearity curve of measured vs. expected value for creatinine using the ABL90 FLEX PLUS.

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  Fig. 2 Scatter plots and regression lines comparing the ABL90 FLEX PLUS and the Beckman Coulter AU5800.

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  Fig. 3 Estimated bias of ABL90 FLEX PLUS at the medical decision level.

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  Fig. 4 Bland Altman plot of difference between the Beckman Coulter AU5800 and ABL90 FLEX PLUS.

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