Kidney Res Clin Pract.
2020 Jun;39(2):192-201. 10.23876/j.krcp.19.120.
The differential effects of anemia on mortality in young and elderly end-stage renal disease patients
- Affiliations
-
- 1Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
- 2Department of Internal Medicine-Nephrology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea
- 3Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
- 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
- 5Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
- 6Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea
- 7Clinical Research Center for End-Stage Renal Disease, Daegu, Republic of Korea
- KMID: 2503868
- DOI: http://doi.org/10.23876/j.krcp.19.120
Abstract
- Background
The aim of this study was to compare the effect of anemia on clinical outcomes according to age in patients with end-stage renal disease (ESRD).
Methods
A total of 3,409 patients from the Clinical Research Center for ESRD were included and divided into three groups by age: age < 40 (n = 488), 40 ≤ age < 60 (n = 1,650), and age ≥ 60 (n = 1,271). We compared overall and cardiovascular mortality, and all-cause and cardiovascular hospitalization according to mean hemoglobin (Hb) concentration.
Results
Among participants ≥ 60 years of age, the Hb < 10 g/dL group had greater all-cause mortality (adjusted hazard ratio [HR], 2.098; 95% confidence interval [CI], 1.567-2.808; P < 0.001) than the 10 ≤ Hb < 12 g/dL group, whereas among participants < 40 years of age, the Hb ≥ 12 g/dL group had greater mortality than the 10 ≤ Hb < 12 g/dL group. Moreover, in participants ≥ 60 years of age, the HR for all-cause hospitalization for the Hb < 10 g/dL group was significantly greater than that of the 10 ≤ Hb < 12 g/dL group (HR, 1.472; 95% CI, 1.057-2.051; P = 0.022), whereas it was significantly lower in the Hb ≥ 12 g/dL group (HR, 0.544; 95% CI, 0.362-0.820; P = 0.004) However, among participants < 40 years of age, the incidence of all-cause hospitalization did not differ according to the Hb concentration (HR, 1.273; 95% CI, 0.814-1.991; P = 0.290 for the Hb < 10 g/dL group; reference, 10 ≤ Hb < 12 g/dL; HR, 0.787; 95% CI, 0.439-1.410; P = 0.265 for Hb ≥ 12 g/dL group).
Conclusion
The impact of anemia on mortality was more significant in elderly ESRD patients. Strict monitoring and management of anemia should be required for elderly ESRD patients.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Anemia and nutrition in end stage renal disease patient
- Therapeutic Consideration for the Elderly Patients with End Stage Renal Disease
- Major changes and improvements of dialysis therapy in Korea: review of end-stage renal disease registry
- Anemia in Elderly Koreans
- Current characteristics of dialysis therapy in Korea: 2015 registry data focusing on elderly patients
