J Obes Metab Syndr.  2020 Jun;29(2):114-123. 10.7570/jomes19079.

Non-nutritive Sweeteners and Their Associations with Obesity and Type 2 Diabetes

• Walbolt J
• Koh Y

• KMID: 2503840
• DOI: http://doi.org/10.7570/jomes19079

Abstract

Evidence linking the excessive consumption of nutritive sweeteners (NS) to adverse metabolic health outcomes has led to an increase in consumption of non-nutritive sweeteners (NNS), particularly among the obese and individuals with diabetes. NNS are characterized by having zero-to-negligible caloric load, while also having a sweet taste. They are utilized as a replacement for traditional NS to reduce energy intake and to limit carbohydrate-related negative health outcomes. However, recent studies have suggested that NNS may actually contribute to the development or worsening of metabolic diseases, including metabolic syndrome, obesity, type 2 diabetes, and cardiovascular disease. Thus, it is imperative to understand the NNS efficacy and the relationship between NNS and metabolic diseases.

Keyword

Stevia; Diabetes; Aspartame; Sucralose; Glucose; Obesity