Keimyung Med J.  2020 Jun;39(1):23-27. 10.46308/kmj.2020.00108.

Absence of Clinical Value of TZAP Mutation and Expression in Non-small Cell Lung Cancers

• Lee DH
• Jung SJ
• Lee JH

• KMID: 2502847
• DOI: http://doi.org/10.46308/kmj.2020.00108

Abstract

The zinc finger protein ZBTB48 is a telomere-associated factor and renamed it as telomeric zinc finger-associated protein (TZAP). It binds preferentially to long telomeres competing with TRF1 and TRF2. However, its mutation in cancers has not been studied. In the present study, we analyzed TZAP mutation in 134 non-small cell lung cancers (NSCLCs). And its big data analysis was performed using COSMIC and TCGA data analysis. TZAP mutation was not found in 134 NSCLCs. And big data also showed that TZAP mutation was extremely low (0.59%, 15/2548). TCGA survival analysis showed no prognostic value of TZAP expression in lung adenocarcinoma (p = 0.185) and squamous cell carcinoma (p = 0.817). When stratified patients sorting as 25:25 (quarter), it has a significance (p = 0.003). This result suggested that genetic change of TZAP did not appear to be a possible molecular marker in lung cancer.

Keyword

Non-small cell lung cancers; Telomere; TZAP; ZBTB48