Asian Spine J.  2020 Jun;14(3):312-319. 10.31616/asj.2019.0266.

Evaluating Spinal Canal Lesions Using Apparent Diffusion Coefficient Maps with Diffusion-Weighted Imaging

• Kanamoto H
• Norimoto M
• Eguchi Y
• Oikawa Y
• Orita S
• Inage K
• Abe K
• Inoue M
• Kinoshita H
• Umimura T
• Matsumoto K
• Masuda Y
• Furuya T
• Koda M
• Aoki Y
• Watanabe A
• Takahashi K
• Ohtori S

• KMID: 2502723
• DOI: http://doi.org/10.31616/asj.2019.0266

Abstract

Study Design: Observational study. Purpose: To evaluate healthy volunteers and patients with spinal canal lesions using apparent diffusion coefficient (ADC) maps with diffusion-weighted imaging. Overview of Literature: Decompression surgery for lumbar spinal stenosis (LSS) is selected on the basis of subjective assessment and cross-sectional magnetic resonance imaging (MRI). However, there is no objective standard for this procedure.
Methods
We performed 3T MRI in 10 healthy volunteers and 13 patients with LSS. The ADC values in the spinal canal were evaluated at 46 vertebrae (L4/5 and L5/S1 for each participant), and the reduced and conventional fields of view were compared.
Results
The ADC values were 2.72±0.12 at L4/5 in healthy volunteers, 2.76±0.19 at L5/S1 in healthy volunteers, 1.77±0.58 at L4/5 in patients with LSS, and 2.35±0.29 at L5/S1 in patients with LSS. The ADC value at L4/5 in patients with LSS was significantly lower than that at L5/S1 in patients with LSS and that at L4/5 and L5/S1 in healthy volunteers (p <0.05). With an ADC cutoff value of 2.46 to identify LSS, this approach provided an area under the curve of 0.81, sensitivity of 0.92, and specificity of 0.76 (p <0.05).
Conclusions
Preoperative examination using ADC maps permits visualization and quantification of spinal canal lesions, thus proving the utility of ADC maps in the selection of decompression surgery for LSS.

Keyword

Spinal canal lesions; Diffusion-weighted imaging; Apparent diffusion coefficient map; Decompression surgery