J Vet Sci.  2014 Sep;15(3):455-458. 10.4142/jvs.2014.15.3.455.

Clinical applications and characteristics of apparent diffusion coefficient maps for the brain of two dogs

• Kim B
• Yi K
• Jung S
• Ji S
• Choi M
• Yoon J

• KMID: 2155632
• DOI: http://doi.org/10.4142/jvs.2014.15.3.455

Abstract

Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping are functional magnetic resonance imaging techniques for detecting water diffusion. DWI and the ADC map were performed for intracranial lesions in two dogs. In necrotizing leukoencephalitis, cavitated lesions contained a hypointense center with a hyperintense periphery on DWI, and hyperintense signals on the ADC maps. In metastatic sarcoma, masses including a necrotic region were hypointense with DWI, and hyperintense on the ADC map with hyperintense perilesional edema on DWI and ADC map. Since DWI and ADC data reflect the altered water diffusion, they can provide additional information at the molecular level.

Keyword

apparent diffusion coefficient map; brain; diffusion-weighted imaging; dog; magnetic resonance image

MeSH Terms

Animals
Brain/*pathology
Brain Neoplasms/pathology/*veterinary
Diffusion Magnetic Resonance Imaging/*veterinary
Dog Diseases/*pathology
Dogs
Female
Leukoencephalopathies/pathology/*veterinary
Necrosis/veterinary
Neuroimaging/*veterinary
Sarcoma/pathology/*veterinary

Figure

• 

  Fig. 1 Transverse magnetic resonance (MR) images of Case 1. There was a marked cavitary lesion in the left occipital lobe. This cavitated lesion appeared hypointense on the T1-weighted (T1W) image (A) without contrast enhancement (B). The T2-weighted (T2W) image (C) had marked hyperintensity in this region. On the fluid-attenuated inversion recovery image (D), the lesion contained a hypointense center with a hyperintense periphery. On the diffusion images, the cavitated lesion contained a hypointense center with a hyperintense periphery on the diffusion-weighted imaging (DWI) (E) and a hyperintense signal on the apparent diffusion coefficient (ADC) maps (F).

• 

  Fig. 2 Transverse MR images of Case 2. There were multiple round masses in the forebrain with a mass effect. The masses contained an isointense signal on the T1W image (A) without contrast enhancement (B) along with isointense to hypointense signals on the T2W images (C). These lesions had a low signal on DWI analysis (E) and a high signal on the ADC map (F). Perilesional edema generated a hyperintense signal with DWI (E) and on the ADC map (F).

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