J Rheum Dis.  2020 Jan;27(1):30-36. 10.4078/jrd.2020.27.1.30.

Echocardiographic Evaluation of Axial Spondyloarthritis in Korea: Data From the Catholic Axial Spondyloarthritis Cohort

• Min HK
• Lee J
• Ju JH
• Kwok SK
• Youn HJ
• Park SH

• KMID: 2471959
• DOI: http://doi.org/10.4078/jrd.2020.27.1.30

Abstract

OBJECTIVE
Axial spondyloarthritis (axSpA) is often accompanied by cardiac manifestations, such as valvular heart disease. In this prospective cohort study, we evaluated the incidence of cardiac abnormalities in Korean axSpA patients by echocardiography.
METHODS
AxSpA patients were prospectively recruited from a single tertiary hospital. Baseline demographic, clinical, radiographic, and echocardiographic data were collected at the time of enrollment. Echocardiography evaluations were performed with a focus on valvular heart disease and systolic and diastolic function. Logistic regression analyses were used to identify factors associated with diastolic dysfunction in axSpA.
RESULTS
A total of 357 axSpA patients were included in the analyses, of whom 78 (21.8%) exhibited diastolic dysfunction, with no reports of systolic dysfunction. Thirteen patients (3.6%) had valvular heart disease, and aortic valve regurgitation (n=5) and mitral valve regurgitation (n=6) were most common. Multivariable logistic regression analyses indicated that older age and higher body mass index (BMI) were positively associated with diastolic dysfunction, whereas human leukocyte antigen (HLA)-B27 positivity was negatively associated with diastolic dysfunction.
CONCLUSION
Valvular heart disease is infrequent in Korean axSpA patients. However, diastolic dysfunction is common in axSpA patients, and is significantly associated with older age, higher BMI, and HLA-B27.

Keyword

Spondylarthropathies; Echocardiography; Heart failure, diastolic; Heart valve diseases

MeSH Terms

Aortic Valve
Body Mass Index
Cohort Studies*
Echocardiography*
Heart Failure, Diastolic
Heart Valve Diseases
HLA-B27 Antigen
Humans
Incidence
Korea*
Leukocytes
Logistic Models
Mitral Valve Insufficiency
Prospective Studies
Spondylarthropathies
Tertiary Care Centers
HLA-B27 Antigen

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