J Korean Ophthalmol Soc.  2020 Mar;61(3):258-266. 10.3341/jkos.2020.61.3.258.

Comparison of Clinical Characteristics between Patients with Cytomegalovirus Positive and Negative Hypertensive Uveitis

• Kim JH
• Lee JY
• Choi JA

• KMID: 2471766
• DOI: http://doi.org/10.3341/jkos.2020.61.3.258

Abstract

PURPOSE
To compare the clinical characteristics of hypertensive uveitis patients, with and without cytomegalovirus (CMV) infection.
METHODS
CMV polymerase chain reaction (PCR) was performed on the aqueous humor of 61 patients with hypertensive uveitis. Patients were divided into CMV positive and negative groups. Sex, age, age at first attack and at first diagnosis, duration of attack, number of attacks, interval between attacks, and surgical history were investigated, and the visual acuity, intraocular pressure (IOP), and corneal endothelial cell density were measured. Blood tests were conducted to determine the inflammation index, antibody titers of CMV, and herpes simplex virus, with toxoplasma and toxocariasis evaluations. With these results, the differences between the two groups were confirmed.
RESULTS
Compared with the CMV negative group, the CMV positive group showed a significantly higher trough IOP (p = 0.007) and a greater difference in corneal endothelial cell counts of the affected eye and the fellow eye (p = 0.048). The CMV positive group exhibited iris degeneration (73.3%), whereas the CMV negative group showed lesions in 47.8% (p = 0.085). No statistically significant differences between the two groups were evident in terms of leukocyte count, inflammation index, antibody titers to CMV, HSV, toxoplasma, or toxocariasis.
CONCLUSIONS
CMV anterior uveitis was characterized by high IOP and corneal endothelial cell loss in the affected eyes. The CMV positive group had more corneal lesions and iris degeneration than the CMV negative group; however, the two groups showed no significant serological differences. When the clinical features of hypertensive uveitis are present, a routine corneal endothelium test and CMV PCR should be performed periodically, to initiate antiviral agent treatments along with IOP and inflammation controls.

Keyword

Cytomegalovirus; Ocular hypertension; Uveitis; Uveitic glaucoma

MeSH Terms

Aqueous Humor
Corneal Endothelial Cell Loss
Cytomegalovirus*
Diagnosis
Endothelial Cells
Endothelium, Corneal
Hematologic Tests
Humans
Inflammation
Intraocular Pressure
Iris
Leukocyte Count
Ocular Hypertension
Polymerase Chain Reaction
Simplexvirus
Toxocariasis
Toxoplasma
Uveitis*
Uveitis, Anterior
Visual Acuity

Figure

• 

  Figure 1 Peak and trough intraocular pressure (IOP) of cytomegalovirus (CMV)-positive and CMV-negative hypertensive uveitis. In the CMV polymerase chain reaction (PCR) positive patients, the peak IOP during the duration of the disease was found to be lower than that of the negative patients, but no statistically significant difference was observed (p = 0.199). However, the trough IOP during the duration of the disease was statistically significantly higher in the CMV PCR-positive patients than in the negative patients (p = 0.007). *Student's t-test; †Mann-Whitney's U-test.

• 

  Figure 2 Baseline and intereye differences of corneal endothelial cell density of cytomegalovirus (CMV)-positive and CMV-negative hypertensive uveitis patients. A lower corneal endothelial cell density was found in the CMV polymerase chain reaction positive patients, but no statistically significant difference was noted (p = 0.244, student's t-test). However, we also examined the corneal endothelial cell density in the opposite eye to determine the difference in binocularity, and the results showed a significant difference between CMV-positive and negative groups (p = 0.048, Mann-Whitney's U-test). ECD = endothelial cell count.

• 

  Figure 3 Different corneal manifestations of cytomegalovirus (CMV) positive hypertensive anterior uveitis patients. A 25-year-old female patient with CMV-positive anterior uveitis showed a coin-like lesion (A) and a 55-year-old male patient showed ring-like opacity (B). In addition, a 27-year-old male patient showed a simple keratic precipitate (C) and a 72-year-old male patient showed multiple keratitic precipitate with iris pigmentation (D).

• 

  Figure 4 Iris changes associated with cytomegalovirus positive hypertensive anterior uveitis. When compared to the normal opposite eye (A), the iris atrophy was observed within the affected left eye (B) of a 25-year-old female patient. A 60-year-old male patient showed a spongy-like change of inferior iris stroma of the affected eye (D), compared to the normal opposite eye (C).

• 

  Figure 5 Serial changes of a 55-year-old male patient. At baseline examination, superior ring-like opacity of the cornea was shown (A) and after 2 months, aggravation of ring like opacity was observed (B). Round stromal opacity at the center of the ring-like opacity appeared 5 months later (C). After 7 months, ring like opacity was improved (D).

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