Endocrinol Metab.  2020 Mar;35(1):36-43. 10.3803/EnM.2020.35.1.36.

Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations

Affiliations
  • 1Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, USA. xl15@nyu.edu
  • 2Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
  • 3Perlmutter Cancer Institute, New York University Grossman School of Medicine, New York, NY, USA.
  • 4Department of Urology, New York University Grossman School of Medicine, New York, NY, USA.

Abstract

Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory role. Taken with the fact that succinate is an intermediate metabolite in the center of mitochondrial activity, and considering its potential regulation of protein succinylation through succinyl-coenzyme A, a review on the overall multifaceted actions of succinate to discuss whether and how these actions relate to the cellular locations of succinate is much warranted. Mechanistically, it is important to consider the sources of succinate, which include somatic cellular released succinate and those produced by the microbiome, especially the gut microbiota, which is an equivalent, if not greater contributor of succinate levels in the body. Continue learning the critical roles of succinate signaling, known and unknown, in many pathophysiological conditions is important. Furthermore, studies to delineate the regulation of succinate levels and to determine how succinate elicits various types of signaling in a temporal and spatial manner are also required.

Keyword

Succinates; Microbiota; Inflammation; SUCNR1 protein; Periodontitis

MeSH Terms

Gastrointestinal Microbiome
Inflammation
Learning
Microbiota
Periodontitis
Succinates
Succinic Acid*
Succinates
Succinic Acid
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