Investig Clin Urol.  2020 Mar;61(2):166-172. 10.4111/icu.2020.61.2.166.

BRCA1-associated protein 1 expression and prognostic role in prostate adenocarcinoma

Affiliations
  • 1Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea. chkap@korea.ac.kr
  • 2Department of Urology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Abstract

PURPOSE
As prostate cancer (PCa) is the second most commonly diagnosed cancer worldwide, finding novel markers for prognosis is crucial. BRCA1-associated protein 1 (BAP-1), a nuclear-localized deubiquitinating enzyme, has been reported in several human cancers. However, its prognostic role in PCa remains unknown. Herein, we assessed the prognostic and clinicopathologic significance of BAP-1 in PCa.
MATERIALS AND METHODS
Seventy surgical specimens from radical prostatectomy cases were examined. Two cores per case were selected for construction of tissue microarrays (TMAs). After the exclusion of two cases because of tissue sparsity, BAP-1 immunohistochemical expression was evaluated in 68 cases of formalin-fixed, paraffin-embedded TMA tissue blocks. The immunohistochemical stain was scored according to proportion of nuclear staining: negative (<10% of tumor cells) or positive (≥10% of tumor cells).
RESULTS
BAP-1 expression was negative in 30 cases (44.1%) and positive in 38 cases (55.9%). Positive BAP-1 expression was more common in pT3b disease than in pT2 (p=0.038). A high preoperative prostate-specific antigen level was correlated with BAP-1 expression (p=0.014). Age, lymphovascular invasion, perineural invasion, and grade group were not significantly correlated with BAP-1 expression. Patients with positive BAP-1 expression showed significantly shorter disease-free survival (p=0.013). Additionally, BAP-1 was an independent prognostic factor of PCa (p=0.035; hazard ratio, 9.277; 95% confidence interval, 1.165-73.892).
CONCLUSIONS
Our study findings showed an association of BAP-1 expression with poor PCa prognosis and suggest a potential role for BAP-1 as a prognostic biomarker for PCa.

Keyword

BAP1 protein; Prognosis; Prostatic neoplasms; Survival

MeSH Terms

Adenocarcinoma*
Disease-Free Survival
Humans
Passive Cutaneous Anaphylaxis
Prognosis
Prostate*
Prostate-Specific Antigen
Prostatectomy
Prostatic Neoplasms
Prostate-Specific Antigen
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