J Lipid Atheroscler.  2020 Jan;9(1):153-161. 10.12997/jla.2020.9.1.153.

Select Macrophage Noncoding RNAs of Interest in Cardiovascular Disease

Affiliations
  • 1Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ebthorp@northwestern.edu

Abstract

Cardiovascular disease remains a leading cause of morbidity and mortality worldwide. Aspects of disease severity that are associated with heightened inflammation, such as during atherosclerosis or after myocardial infarction, are correlated with macrophage activation and macrophage polarization of the transcriptome and secretome. In this setting, non-coding RNAs (ncRNAs) may be as abundant as protein-coding genes and are increasingly recognized as significant modulators of macrophage gene expression and cytokine secretion, although the functions of most ncRNAs"”and in particular, long non-coding RNAs"”remain unknown. Herein, we discuss a subset of specific ncRNAs of interest in macrophages in atherosclerosis and during myocardial inflammation.

Keyword

LncRNA; Macrophages; Cardiovascular diseases

MeSH Terms

Atherosclerosis
Cardiovascular Diseases*
Gene Expression
Inflammation
Macrophage Activation
Macrophages*
Mortality
Myocardial Infarction
RNA, Long Noncoding
RNA, Untranslated*
Transcriptome
RNA, Long Noncoding
RNA, Untranslated
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