Korean J Urol Oncol.  2019 Dec;17(3):195-198. 10.22465/kjuo.2019.17.3.195.

Prostate Carcinosarcoma Developing After Combined Pelvic External Beam Radiation Therapy and Androgen Deprivation Therapy

• Kim YJ

• KMID: 2470406
• DOI: http://doi.org/10.22465/kjuo.2019.17.3.195

Abstract

Carcinosarcoma of the prostate is a very rare disease, which consists of carcinomatous and sarcomatous components. The prognosis of patients with prostatic carcinosarcoma is poor. An 80-year-old man who had been suffering from urinary retention and constipation with rectal pain visited a hospital. A patient with a history of combined pelvic external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT) for prostate adenocarcinoma 7 years ago was diagnosed with secondary malignancy such as prostate carcinosarcoma by prostate biopsy. This is also a rare case occurring after combined EBRT and ADT for adenocarcinoma in a short interval. Then, he underwent chemotherapy for one cycle. Chemotherapy was stopped because of rapid clinical aggravation, and the patient died 5 months later. It is important to keep in mind the possibility of carcinosarcoma in the case that prostate-specific antigen maintains stable level but extent of tumor is gradually increased after EBRT or ADT.

Keyword

Prostate; Carcinosarcoma; Prognosis

MeSH Terms

Adenocarcinoma
Aged, 80 and over
Biopsy
Carcinosarcoma*
Constipation
Drug Therapy
Humans
Prognosis
Prostate*
Prostate-Specific Antigen
Rare Diseases
Urinary Retention
Prostate-Specific Antigen