Lab Anim Res.
2019 Dec;35(4):202-212. 10.1186/s42826-019-0025-x.
An improvement in acute wound healing in rats by the synergistic effect of photobiomodulation and arginine
- Mostafavinia A
- Bidram M
- Avili AG
- Mahmanzar
- Karimifard SA
- Sajadi E
- Amini A
- Hadipour Jahromy M
- Ghoreishi
- Chien S
- Bayat M
- Affiliations
-
- 1Department of Anatomy, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
- 2Department of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
- 3Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
- 4Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
- 5Department of Biology and Anatomical sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- 6Herbal pharmacology Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
- 7Department of Statistics, University of Qom, Qom, Iran.
- 8Price Institute of Surgical Research, University of Louisville and Noveratech LLC of Louisville, Louisville, KY, USA. bayat_m@yahoo.com
- 9Department of Biology and Anatomical sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
- KMID: 2470018
- DOI: http://doi.org/10.1186/s42826-019-0025-x
Abstract
- In this probe, at first we examined the best route and dosage of arginine administration on wound healing in an excisional wound model in rats. Next, we intend to assess the impact of photobiomodulation (PBM) and arginine, individually and together, on the wound healing. In the pilot study, an excisional wound was made in each of 24 rats. There were 4 groups. Group 1 was the control group. In groups 2 and 3, wounds were topically treated with arginine ointments (ARG.) 2% and 5%, respectively. In group 4, arginine was injected (ARG. INJ.,i.p.). In the main phase, in 24 new rats, an excisional wound was made. There were 4 groups: group 5 served as the control. Wounds in group 6 were topically treated with ARG 2%. Wounds in group 7 were subjected to PBM. Wounds in group 8 were treated with PBM+ARG. 2%. On day 15, wound area measurement, wound strength, and stereological examination were performed. In the pilot study, we found that the ARG 2% ointment significantly decreased wound area than ARG. 5%, ARG. INJ. and control groups, and significantly increased wound strength compared to the control and ARG.5% groups. In the main phase, a significant decrease of wound area in all treatment regimens was induced. PBM + ARG. 2% and PBM treatment regimens significantly improved wound strength and almost all stereological parameters, compared to the control and ARG. 2% groups. PBM + ARG. 2% induced anti-inflammatory and angiogenic activities, and hastened the wound healing process in an excisional wound model in rats.
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