Korean J Otorhinolaryngol-Head Neck Surg.  2019 Dec;62(12):740-746. 10.3342/kjorl-hns.2019.00409.

Intrathyroidal Parathyroid Carcinoma in Chronic Kidney Disease: A Case Report and Review of Literature

• Kim MK
• Song CM
• Tae K
• Ji YB

• KMID: 2469961
• DOI: http://doi.org/10.3342/kjorl-hns.2019.00409

Abstract

When parathyroid carcinoma occurs in the thyroid gland, it is very difficult to diagnose before surgery because imaging studies and aspiration cytology cannot distinguish parathyroid carcinoma from thyroid nodule or benign parathyroid disease. A 53-year-old male was referred to our hospital for assessment of hypercalcemia. He had suffered from chronic kidney disease for 13 years. A 2.5×1.5 cm hypoechoic nodule was noted in the left thyroid gland on ultrasonography, and it showed increased uptake on the sestamibi scan. Fine needle aspiration biopsy revealed it to be a parathyroid lesion, which was confirmed by surgery as parathyroid carcinoma completely surrounded by normal thyroid parenchyme. Because ultrasonography and aspiration cytology have only a limited role in distinguishing parathyroid carcinoma from thyroid neoplasm, suspicion of parathyroid carcinoma before or during surgery through careful examination can lead to complete resection at the initial surgery.

Keyword

Chronic kidney disease; Hyperparathyroidism; Parathyroid carcinoma; Thyroid nodule

MeSH Terms

Biopsy
Biopsy, Fine-Needle
Humans
Hypercalcemia
Hyperparathyroidism
Male
Middle Aged
Parathyroid Diseases
Parathyroid Neoplasms*
Renal Insufficiency, Chronic*
Thyroid Gland
Thyroid Neoplasms
Thyroid Nodule
Ultrasonography