Korean J Otorhinolaryngol-Head Neck Surg.  2019 Dec;62(12):675-680. 10.3342/kjorl-hns.2019.00710.

Development of Artificial Substitutes for Upper Digestive Tract: Personal Experience of Trials and Errors

• Chung EJ

• KMID: 2469951
• DOI: http://doi.org/10.3342/kjorl-hns.2019.00710

Abstract

The current treatments for esophageal diseases, such as carcinomas, trauma or congenital malformations, require surgical intervention, and esophageal reconstruction using redundant parts of the gastrointestinal tract. However, the use of gastrointestinal segments can cause various surgical morbidities and mortality because additional abdominal surgery may be required at the expense of other anatomic structures. Therefore, tissue engineering using various biomaterial or cell sources has emerged as an alternative strategy of biomimicking the native esophageal tissue that could be implanted as an artificial graft. Although tissue engineering techniques have promise as an effective regenerative strategy, no functional solution currently exists for esophageal reconstruction. Here, we present a review of the progress made in the field of regenerative medicine for esophageal reconstruction based on the personal experience.

Keyword

Epithelial cell; Esophagus; Smooth muscle cell; Tissue engineering; Tissue scaffolds

MeSH Terms

Epithelial Cells
Esophageal Diseases
Esophagus
Gastrointestinal Tract*
Humans
Mortality
Myocytes, Smooth Muscle
Regenerative Medicine
Tissue Engineering
Tissue Scaffolds
Transplants