Biomed Eng Lett.  2019 May;9(2):153-168. 10.1007/s13534-019-00094-z.

Methods for evaluating effects of unloader knee braces on joint health: a review

• Parween R
• Shriram D
• Mohan RE
• Lee YH
• Subburaj K

• KMID: 2469502
• DOI: http://doi.org/10.1007/s13534-019-00094-z

Abstract

The paper aims to provide a state-of-the-art review of methods for evaluating the effectiveness and effect of unloader knee braces on the knee joint and discuss their limitations and future directions. Unloader braces are prescribed as a non-pharmacological conservative treatment option for patients with medial knee osteoarthritis to provide relief in terms of pain reduction, returning to regular physical activities, and enhancing the quality of life. Methods used to evaluate and monitor the effectiveness of these devices on patients' health are categorized into three broad categories (perception-, biochemical-, and morphology-based), depending upon the process and tools used. The main focus of these methods is on the short-term clinical outcome (pain or unloading efficiency). There is a significant technical, research, and clinical literature gap in understanding the short- and long-term consequences of these braces on the tissues in the knee joint, including the cartilage and ligaments. Future research directions may complement existing methods with advanced quantitative imaging (morphological, biochemical, and molecular) and numerical simulation are discussed as they offer potential in assessing long-term and post-bracing effects on the knee joint.

Keyword

Unloader knee brace; Knee osteoarthritis; Quantitative imaging; Finite element modelling; Post-bracing effects

MeSH Terms

Braces*
Cartilage
Complement System Proteins
Humans
Joints*
Knee Joint
Knee*
Ligaments
Methods*
Motor Activity
Osteoarthritis, Knee
Quality of Life
Review Literature as Topic
Complement System Proteins