J Vet Sci.  2020 Jan;21(1):e6. 10.4142/jvs.2020.21.e6.

Comparison of the trometamol-balanced solution with two other crystalloid solutions for fluid resuscitation of a rat hemorrhagic model

Affiliations
  • 1Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan. jacklee@ntu.edu.tw
  • 2Cardiovascular Surgery, Department of Surgery, National Taiwan University Hospital, National Taiwan University, Taipei 10002, Taiwan. yschen1234@gmail.com
  • 3Graduate Institute of Veterinary Clinical Sciences, School of Veterinary Medicine, National Taiwan University, Taipei 10672, Taiwan.
  • 4Animal Cancer Treatment Center, National Taiwan University Veterinary Hospital, Taipei 10672, Taiwan.

Abstract

Currently, the optimal resuscitation fluid remains debatable. Therefore, in the present study, we designed a trometamol-balanced solution (TBS) for use as a resuscitation fluid for hemorrhagic shock. Hemorrhagic shock was induced in 18 male Wistar-Kyoto rats, which were assigned to normal saline (NS), Ringer's solution (RS), and TBS groups. During the hemorrhagic state, their hemodynamic parameters were recorded using an Abbott i-STAT analyzer with the CG4+ cartridge (for pH, pressure of carbon dioxide, pressure of oxygen, total carbon dioxide, bicarbonate, base excess, oxygen saturation, and lactate), the CG6+ cartridge (for sodium, potassium, chloride, blood glucose, blood urea nitrogen, hematocrit, and hemoglobin), and enzyme-linked immunosorbent assay kits (calcium, magnesium, creatinine, aspartate aminotransferase, alanine aminotransferase, bilirubin, and albumin). Similar trends were found for the parameters of biochemistries, electrolytes, and blood gas, and they revealed no significant changes after blood withdrawal-induced hemorrhagic shock. However, the TBS group showed more effective ability to correct metabolic acidosis than the NS and RS groups. TBS was a feasible and safe resuscitation solution in this study and may be an alternative to NS and RS for resuscitation in hemorrhagic shock patients without liver damage.

Keyword

Resuscitation fluid; normal saline; Ringer's solution; hemorrhagic model

MeSH Terms

Acidosis
Alanine Transaminase
Animals
Aspartate Aminotransferases
Bilirubin
Blood Glucose
Blood Urea Nitrogen
Carbon Dioxide
Creatinine
Electrolytes
Enzyme-Linked Immunosorbent Assay
Hematocrit
Hemodynamics
Humans
Hydrogen-Ion Concentration
Liver
Magnesium
Male
Oxygen
Potassium
Rats*
Resuscitation*
Shock, Hemorrhagic
Sodium
Alanine Transaminase
Aspartate Aminotransferases
Bilirubin
Blood Glucose
Carbon Dioxide
Creatinine
Electrolytes
Magnesium
Oxygen
Potassium
Sodium
Full Text Links
  • JVS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error