Korean J Anesthesiol.  1993 Aug;26(4):658-665. 10.4097/kjae.1993.26.4.658.

Crystalloid Resuscitation in Experimental Hemorrhagic Shock in Dogs

• Lee ST
• Cho IC
• Park YC
• Chung KS

• KMID: 2236977
• DOI: http://doi.org/10.4097/kjae.1993.26.4.658

Abstract

Although crystalloid solutions such as Ringer's lactate have become the standard for initial volume replacement after hemorrhage, it is controversy whether this fluid alone restores and maintains the depressed physiologic function after severe hemorrhage. Six anesthetized dogs were bled(35ml/kg) and resuscitated with Ringers lactate solution (100 ml/kg). Physiologic variables are measured initialy, after hemorrhage, after resucitation. Compared with initial value, after resuscitation data show marked reduction in hemoglobin, oxygen carrying capacity, vascular resistance, and electrolyte. But cardiac output and blood gas analysis data was not changed. Prothrombin time and partial thromboplastin time was prolongated. From this study crystalloid resuscitation in severe hemorrhagic shock restore cardiac output and perfusion, but fail to maintain adequate oxygen carrying capacity.

Keyword

Crystalloid; Hemorrhage; Cardiac output; Oxygen content

MeSH Terms

Animals
Blood Gas Analysis
Cardiac Output
Natural Resources
Dogs*
Hemorrhage
Lactic Acid
Oxygen
Partial Thromboplastin Time
Perfusion
Prothrombin Time
Resuscitation*
Shock, Hemorrhagic*
Vascular Resistance
Lactic Acid
Oxygen