Korean J Radiol.  2017 Feb;18(1):152-161. 10.3348/kjr.2017.18.1.152.

Added Value of Contrast-Enhanced Ultrasound on Biopsies of Focal Hepatic Lesions Invisible on Fusion Imaging Guidance

Affiliations
  • 1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea. leeminwoo0@gmail.com
  • 2Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

Abstract


OBJECTIVE
To assess whether contrast-enhanced ultrasonography (CEUS) with Sonazoid can improve the lesion conspicuity and feasibility of percutaneous biopsies for focal hepatic lesions invisible on fusion imaging of real-time ultrasonography (US) with computed tomography/magnetic resonance images, and evaluate its impact on clinical decision making.
MATERIALS AND METHODS
The Institutional Review Board approved this retrospective study. Between June 2013 and January 2015, 711 US-guided percutaneous biopsies were performed for focal hepatic lesions. Biopsies were performed using CEUS for guidance if lesions were invisible on fusion imaging. We retrospectively evaluated the number of target lesions initially invisible on fusion imaging that became visible after applying CEUS, using a 4-point scale. Technical success rates of biopsies were evaluated based on histopathological results. In addition, the occurrence of changes in clinical decision making was assessed.
RESULTS
Among 711 patients, 16 patients (2.3%) were included in the study. The median size of target lesions was 1.1 cm (range, 0.5-1.9 cm) in pre-procedural imaging. After CEUS, 15 of 16 (93.8%) focal hepatic lesions were visualized. The conspicuity score was significantly increased after adding CEUS, as compared to that on fusion imaging (p < 0.001). The technical success rate of biopsy was 87.6% (14/16). After biopsy, there were changes in clinical decision making for 11 of 16 patients (68.8%).
CONCLUSION
The addition of CEUS could improve the conspicuity of focal hepatic lesions invisible on fusion imaging. This dual guidance using CEUS and fusion imaging may affect patient management via changes in clinical decision-making.

Keyword

Liver; Biopsy; Contrast-enhanced ultrasonography; Fusion imaging; Sonazoid

MeSH Terms

Adult
Aged
Aged, 80 and over
Clinical Decision-Making
Contrast Media/chemistry
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Female
Ferric Compounds/chemistry
Humans
Iron/chemistry
Liver Diseases/*diagnosis/diagnostic imaging/pathology
Male
Middle Aged
Oxides/chemistry
*Positron Emission Tomography Computed Tomography
Retrospective Studies
Young Adult
Contrast Media
Ferric Compounds
Oxides
Iron
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