Nat Prod Sci.  2019 Dec;25(4):293-297. 10.20307/nps.2019.25.4.293.

Physiological Activities of Policosanol Extracted from Sugarcane Wax

• Jang YS
• Kim DE
• Han E
• Jung J

• KMID: 2468061
• DOI: http://doi.org/10.20307/nps.2019.25.4.293

Abstract

Policosanol extracted from sugarcane wax is a generic term used for total fatty alcohols obtained from esterification of fatty acids. It has been approved as a health functional food by the Ministry of Food and Drug Safety of Korea in 2006. Policosanol is well-known to aid in lowering blood cholesterol level. Recently, several studies have reported the physiological activities of policosanol, such as anti-inflammatory effects, antioxidant effects, and lowering of the incidence of ageing-related diseases, for example, hypertension, stroke, among others. This review describes the physiological activities of policosanol and its applications in the field of health functional foods.

Keyword

policosanol; health functional food; sugarcane wax; physiological activities

MeSH Terms

Antioxidants
Cholesterol
Esterification
Fatty Acids
Fatty Alcohols
Functional Food
Hypertension
Incidence
Korea
Saccharum*
Stroke
Antioxidants
Cholesterol
Fatty Acids
Fatty Alcohols

Figure

• 

  Fig. 1. Physiological activities and mechanism of policosanol.

Reference

1.Marinangeli C. P.., Kassis A. N.., Jain D.., Ebine N.., Cunnane S. C.., Jones P. J. Br. J.Nutr. 2007. 97:381–388.

2.Committee for the Korean Guidelines for the Management of Dyslipidemia. Korean Circ. J. 2016. 46:275–306.

3.Marinangeli C. P.., Jones P. J.., Kassis A. N.., Eskin M. N.Crit. Rev. Food Sci. Nutr. 2010. 50:259–267.

4.Liao F.., Chen W.Hubei Agric. Sci. 2013. 52:1125–1127.

5.Singh D. K.., Li L.., Porter T. D. J.Pharmacol. Exp. Ther. 2006. 318:1020–1026.

7.Menendez R.., Amor A. M.., Gonzalez R. M.., Fraga V.., Mas R.Biol. Res. 1996. 29:253–257.

8.Menéndez R.., Arruzazabala L.., Más R.., Del Rio A.., Amor A. M.., González R. M.., Carbajal D.., Fraga V.., Molina V.., Illnait J. Br. J.Nutr. 1997. 77:923–932.

9.Arruzazabala M.L.; Carbajal, D.; Mas, R.; Molina, V.; Valdes, S.; Laguna, A., Biol. Res. 1994. 27:205–208.

10.Arruzazabala M. L.., Carbajal D.., Mas R.., Castano G.., Sotolongo R.., Mesa R.Rev. CENIC Cien. Biol. 1991. 22:60–61.

11.Rodriguez-Echenique C.., Mesa R.., Mas R.., Noa M.., Menendez R.., Gonzalez R. M.., Amor A. M.., Fraga V.., Sotolongo V.., Laguna A.Food Chem. Toxicol. 1994. 32:565–575.

12.Hernandez F.., Illnait J.., Mas R.., Castano G.., Fernández L.., Gonzalez M.., Cordovi N.., Fernandez J. C.Curr. Ther. Res. Clin. Exp. 1992. 51:568–575.

13.Castano G.., Mas R.., Fernandez J.., Lopez E.., Illnait J.., Fernandez L.., Mesa M.Curr. Ther. Res. Clin. Exp. 2003. 64:522–537.

14.Lopez E.., Illnait J.., Fernandez J. C.., Fernandez L.., Gamez R.., Mesa M.., Mendoza S.., Mas R.., Ruiz D.., Jardines Y.Rev. CRNIC Cien. Biol. 2010. 41:31–37.

15.Castano G.., Mas R.., Fernandez L.., Illnait J.., Hernandez E.., Fernandez J.., Gamez R.., Gutierrez C.., Alvarez E.Curr. Ther. Res. 2002. 63:286–303.

16.Illnait J.., López E.., Fernández L.., Mas R.., Gamez R.., Mesa M.., Mendoza S.., Fernández J. C.Int. J. Pharm. Sci. Rev. Res. 2013. 22:303–309.

17.Lin Y.., Rudrum M.., van der Wielen R. P.., Trautwein E. A.., McNeill G.., Sierksma A.., Meijer G. W.Metabolism. 2004. 53:1309–1314.

18.Gouni-Berthold I.., Berthold H. K.Am. Heart J. 2002. 143:356–365.

19.Tang M.., Wu S. Z.., Gong X.Zhonghua Xin Xue Guan Bing Za Zhi. 2013. 41:488–492.

20.Wang H. Y.., Jiao Q. P.., Chen S. Y.., Sheng J.., Jiang H.., Lu J.., Zheng S. B.., Fang N. Y. Am. J.Med. Sci. 2018. 356:254–261.

21.Careskey H. E.., Davis R. A.., Alborn W. E.., Troutt J. S.., Cao G.., Konrad R. J. J.Lipid Res. 2008. 49:394–398.

22.Welder G.., Zineh I.., Pacanowski M. A.., Troutt J. S.., Cao G.., Konrad R. J. J.Lipid Res. 2010. 51:2714–2721.

23.Mousavi S. A.., Berge K. E.., Leren T. P. J.Intern. Med. 2009. 266:507–519.

24.Guo Y. L.., Xu R. X.., Zhu C. G.., Wu N. Q.., Cui Z. P.., Li J. J.Evid. Based Complement. Alternat. Med. 2014. 2014:926087.

25.Lee H. Y. J.Korean Med. Assoc. 2018. 6:485–492.

26.Kim S. J.., Yadav D.., Park H. J.., Kim J. R.., Cho K. H.Front. Physiol. 2018. 9:412.

27.Cho K. H.., Kim S. J.., Yadav D.., Kim J. Y.., Kim J. R.Oxid. Med. Cell. Longev. 2018. 2018:4809525.

28.Fraga V.., Menendez R.., Amor A. M.., Gonzalez R. M.., Jimenez S.., Mas R.Arch. Med. Res. 1997. 28:355–360.

29.Ng C. H.., Leung K. Y.., Huang Y.., Chen Z. Y. J.Agric. Food Chem. 2005. 53:6289–6293.

30.Cicero A. F.., Colletti A.Phytomedicine. 2016. 23:1113–1118.

31.Castano G.., Menendez R.., Mas R.., Amor A.., Fernandez J. L.., Gonzalez R. L.., Lezcay M.., Alvarez E.Int. J. Clin. Pharmacol. Res. 2002. 22:89–99.

32.Harrabi S.., Ferchichi A.., Bacheli A.., Fellah H.Lipids Health Dis. 2018. 17:82.

33.Castano G.., Fernandez L.., Mas R.., Illnait J.., Mesa M.., Fernandez J. C.Clin. Drug Investig. 2003. 23:639–650.

34.Elseweidy M. M.., Zein N.., Aldhamy S. E.., Elsawy M. M.., Saeid S. A.Exp. Biol. Med. 2016. 241:1943–1949.

35.Kaup R. M.., Khayyal M. T.., Verspohl E. J.Phytother. Res. 2013. 27:264–271.

36.Elseweidy M. M.., Mohamed H. E.., Elrashidy R. A.., Atteia H. H.., Elnagar G. M. J.Cardiovasc. Pharmacol. Ther. 2018. 23:551–560.

37.Noa M.., Mas R.., de la Rosa M. C.., Magraner J. J.Pharm. Pharmacol. 1995. 47:289–291.

38.Carbajal D.., Arruzazabala M. L.., Valdes S.., Mas R.Prostaglandins, Leukot. Essent. Fatty Acids. 1998. 58:61–64.

39.Arruzazabala M. L.., Mas R.., Molina V.., Carbajal D.., Mendoza S.., Fernandez L.., Valdes S.Int. J. Tissue React. 1998. 20:119–124.

40.Wong W. T.., Ismail M.., Tohit E. R.., Abdullah R.., Zhang Y. D.Evid. Based Complement. Alternat. Med. 2016. 2016:7343942.

41.Wong W. T.., Ismail M.., Imam M. U.., Zhang Y. D.BMC Complement. Altern. Med. 2016. 16:252.

42.Illnait J.., Castano G.., Alvarez E.., Fernandez L.., Mas R.., Mendoza S.., Gamez R.Angiology. 2008. 59:269–277.

43.Molina V.., Ravelo Y.., Noa M.., Mas R.., Perez Y.., Oyarzabal A.., Mendoza N.., Valle M.., Jimenez S.., Sanchez J.Indian J. Pharm. Sci. 2013. 75:635–641.

44.Ortega L. L.., Sanchez J.., Mas R.., Fernandez L.., Mendoza S.., Gamez R.., Fernandez J. C.., Illnait J.., Alvarez E. J.Med. Food. 2006. 9:378–385.

45.Sánchez J.., Fernández, L. Illnait J.., de Lourdes Arruzazabala M.., Molina V.., Mas R.., Mendoza, S. Carbajal, D. Mesa M.., Fernández J.IOSR J. Pharm. 2012. 2:14–24.

46.Sanchez J.., Illnait J.., Mas R.., Mendoza S.., Fernandez L.., Mesa M.., Vega H.., Fernandez J.., Reyes P.., Ruiz D.Rev. Neurol. 2017. 64:153–161.

47.Sánchez J.., Illnait J.., Mas R.., Mendoza S.., Vega H.., Fernández L.., Mesa M.., Fernández J.., Reyes P.., Ruiz D.Int. J. Pharm. Sci. Rev. Res. 2016. 37:7–14.

48.Sanchez J.., Illnait J.., Mas R.., Perez Y.., Mendoza S.., Cabrera L.., Fernandez L.., Mesa M.., Fernandez J.., Oyarzabal A.., Molona V.., Reyes P.IOSR J. Pham. 2013. 3:31–40.

49.Sanchez-Lopez J.., Fernandez-Travieso J. C.., Illnait-Ferrer J.., Fernandez-Dorta L.., Mendoza-Castano S.., Mas-Ferreiro R.., Mesa-Angarica M.., Reyes-Suarez P.Rev. de Neuro. 2018. 67:331–338.

50.Lee E. Y.., Yoo J. A.., Lim S. M.., Cho K. H.Rejuvenation Res. 2016. 19:149–158.

51.Lim S. M.., Yoo J. A.., Lee E. Y.., Cho K. H.Rejuvenation Res. 2016. 19:59–70.

52.Lee J. H.., Jia Y.., Thach T. T.., Han Y.., Kim B.., Wu C.., Kim Y.., Seo W. D.., Lee S. J.Nutr. Res. 2017. 43:89–99.

53.Lim D.., Ha M.., Song I. J.Korean Med. Sci. 2014. 29:1597–1603.