J Korean Soc Biol Ther Psychiatry.
2019 Oct;25(3):251-256. 10.0000/jksbtp.2019.25.3.251.
Effect of Amyloid Deposition in PET on Hippocampal Metabolism in Amnestic-Mild Cognitive Impairment : Pilot Study
- Affiliations
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- 1Department of Psychiatry, Pusan National University Hospital, Busan, Korea. psyleekr@naver.com
- 2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
- 3Department of Radiology, Pusan National University Hospital, Busan, Korea.
- 4Department of Nuclear Medicine, Pusan National University Hospital, Busan, Korea.
- 5School of Biomedical Engineering and u-HARC, Inje University, Gimhae, Korea.
- 6Department of Psychiatry, Yangsan Pusan National University Hospital, Yangsan, Korea.
- KMID: 2466005
- DOI: http://doi.org/10.0000/jksbtp.2019.25.3.251
Abstract
OBJECTIVES
Most studies of hippocampal metabolism(HM) in amnestic mild cognitive impairment(aMCI) gave inconsistent results. Our objective was to evaluate the effect of amyloid-beta(Aβ) status on hippocampal metabolism in aMCI.
METHODS
Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), ¹â¸F-fluorodeoxyglucose-positron emission tomography(¹â¸FDG-PET) and ¹â¸F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ−aMCI(N=10). The primary outcome was HM using ¹â¸FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ−aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume.
RESULTS
We found that HM was more decreased in Aβ+aMCI than Aβ−aMCI. This result was not changed after controlling hippocampal volume.
CONCLUSION
Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.
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