Korean J Pediatr.  2019 Oct;62(10):367-373. 10.3345/kjp.2019.00178.

Bronchopulmonary dysplasia: how can we improve its outcomes?

Affiliations
  • 1Department of Pediatrics, Hallym University Medical Center, Seoul, Korea. neosung@hallym.or.kr

Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants with multiple factors affected from prenatal to postnatal periods. Despite significant advances in neonatal care over almost 50 years, BPD rates have not decreased; in fact, they may have even increased. Since more preterm infants, even at periviable gestational age, survive today, different stages of lung development affect the pathogenesis of BPD. Hence, the definition of BPD has changed from "old" to "new." In this review, we discuss the various definitions of BPD, risk factors from the prenatal to postnatal periods, management strategies by phase, and future directions for research.

Keyword

Bronchopulmonary dysplasia; Premature infant; Chronic lung disease; Lung injury; Inflammation

MeSH Terms

Bronchopulmonary Dysplasia*
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Inflammation
Lung
Lung Diseases
Lung Injury
Risk Factors
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