Nutr Res Pract.  2019 Oct;13(5):384-392. 10.4162/nrp.2019.13.5.384.

Effect of immune-enhancing enteral nutrition formula enriched with plant-derived n-3 fatty acids on natural killer cell activity in rehabilitation patients

• Cho JM
• Choi HS
• Cho YS
• Park SY
• Kim DY
• Lee JH

• KMID: 2464117
• DOI: http://doi.org/10.4162/nrp.2019.13.5.384

Abstract

BACKGROUND/OBJECTIVES
Enteral nutrition formulas with immune-enhancing nutrients, such as n-3 fatty acids, may manage patients' nutritional status and pathophysiological processes. The aim of our study was to investigate natural killer (NK) cell activity alterations and related cytokine changes resulting from feeding with soybean oil-containing enteral nutrition formula (control group) and plant-derived n-3 fatty acid-enriched enteral nutrition formula.
SUBJECTS/METHODS
Subjects participated for 14 consecutive days and consumed enteral formula containing canola and flaxseed oil (n3EN, test group) in nonsurgical patients hospitalized for rehabilitation. Blood samples were collected on the first day and 14 days after the consumption of each formula daily, and anthropometric parameters were collected. Hematology and biochemical values were analyzed, and NK cell activities and serum cytokine concentration were measured. A total of sixty subjects were included in the analysis, excluding dropouts.
RESULTS
No significant differences were found in biochemical parameters. The n3EN group's NK cell activities at effector:tumor cell ratios of 10:1, 5:1, 2.5:1 and 0.625:1 were significantly higher than those of the control group after two weeks (P < 0.05). However, there were no statistically significant differences in serum cytokine interleukin (IL)-12, interferon-γ, IL-1β, IL-6 and tumor necrosis factor-α values between the two groups.
CONCLUSIONS
In conclusion, this study elucidates the beneficial effects of plant-derived n-3 fatty acid supplementation in enteral formula on NK cell activity.

Keyword

Immune system; enteral nutrition; canola oil; flaxseed oil; natural killer cell

MeSH Terms

Enteral Nutrition*
Fatty Acids, Omega-3*
Hematology
Humans
Immune System
Interleukin-6
Interleukins
Killer Cells, Natural*
Linseed Oil
Necrosis
Nutritional Status
Rehabilitation*
Soybeans
Fatty Acids, Omega-3
Interleukin-6
Interleukins
Linseed Oil

Figure

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  Fig. 1 Flow diagram of randomized participants

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  Fig. 2 Increment of NK cell activities between the two groups at baseline (0 week, ■) and follow up (2 week, □). Values are Mean ± SE. P-values were derived from independent t-tests.

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