Obstet Gynecol Sci.  2019 Nov;62(6):478-482. 10.5468/ogs.2019.62.6.478.

A case of endometrial glassy cell carcinoma: a rare entity which necessitates of better understanding

• Callegari
• Algeri P
• Buzzi A
• Motta T
• Manfredini C
• Rota SM

• KMID: 2462128
• DOI: http://doi.org/10.5468/ogs.2019.62.6.478

Abstract

Endometrial glassy cell carcinoma (EGCC) is a rare neoplasm, accounting for 0.5% of the carcinomas in the endometrium, composed of cells with granular eosinophilic or amphophilic cytoplasm, giving it a ground glass appearance. Till date, only 14 cases of this carcinoma have been reported. In this report, we have described a case of EGCC to help define standard diagnostic criteria and better understand the course, ideal treatment, and accurate prognosis of this disease. We report a case of a 64-year-old woman diagnosed with EGCC after an abnormal pap smear. She underwent a hysteroscopy, which led to the histological diagnosis. Laparotomic total hysterectomy and bilateral salpingo-oophorectomy were performed with pelvic lymphadenectomy and peritoneal and omental biopsies. Final pathological examination confirmed the initial diagnosis. Pelvic nodes removed during surgery and peritoneal and omental biopsies were negative for tumor cells. Treatment was considered appropriate and the patient did not require additional therapies. She was subsequently assigned to clinical follow-up and is alive, with no evidence of the disease.

Keyword

Endometrial cancer; Glassy cell carcinoma; Uterine cancer

MeSH Terms

Biopsy
Cytoplasm
Diagnosis
Endometrial Neoplasms
Endometrium
Eosinophils
Female
Follow-Up Studies
Glass
Humans
Hysterectomy
Hysteroscopy
Lymph Node Excision
Middle Aged
Papanicolaou Test
Prognosis
Uterine Neoplasms

Figure

• 

  Fig. 1 Hematoxylin and eosin staining (20×): Neoplasia characterized by ground glass cells with large nuclei associated with inflammatory cell infiltration.

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