Ann Dermatol.  2019 Dec;31(6):678-680. 10.5021/ad.2019.31.6.678.

Synchronous Orofacial Granulomatosis in a Patient with Brain Cavernous Hemangioma

• Yun SJ
• Lee JY
• Kim GH
• Jeong JH
• Lee AY
• Lee SH
• Hong JS

• KMID: 2461993
• DOI: http://doi.org/10.5021/ad.2019.31.6.678

Abstract

Orofacial granulomatosis is a rare granulomatous inflammatory disease, characterized by recurrent orofacial swelling. Infectious, genetic, and immunologic etiologies are suggested, but not fully understood. Herein, we report a case of synchronous orofacial granulomatosis with brain cavernous hemangioma in a 44-year-old female patient, which may be considered paraneoplastic syndrome.

Keyword

Cavernous hemangioma; Orofacial granulomatosis; Paraneoplastic syndrome

MeSH Terms

Adult
Brain*
Female
Granulomatosis, Orofacial*
Hemangioma, Cavernous
Hemangioma, Cavernous, Central Nervous System*
Humans
Paraneoplastic Syndromes

Figure

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  Fig. 1 (A, B) Erythema and swelling on the right lower lip and perioral area before treatment. (C) Improvement after stereotactic radiosurgery.

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  Fig. 2 (A) Large expansile lobulated mass involving left clivus, petrous bone, left cavernous sinus. (B, C) Serial decrease in tumor size after stereotactic radiosurgery. (A~C) T2-weighted magnetic resonance images.

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  Fig. 3 (A, B) Dense perivascular and perifollicular lymphohistiocytic infiltration (H&E: original magnifications A, ×100; B, ×400).

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