J Korean Soc Endocrinol.  1994 Dec;9(4):344-349.

Changes of Bone Turnover Markers after Treatment with Growth Hormone Therapy in Children with Growth Retardation

• Yang IM
• Woo JT
• Kim SW
• Kim JW
• Kim YS
• Choi YK
• han KO
• Kim DY
• Yang HI

Abstract

The effects of growth hormone(GH) deficiency and recombinant human GH replacement(0.5IU/kg per week) on bone mineral metabolism in 21GH-deficiency children were studied. All children had significantly reduction of bone density(Z score;-1.4+-0.71). After 1 month of therapy, the levels of serum insulin-like growth factor 1(IGF-1), osteocalcin(OC) and carboxyterminal propeptede of type 1 procollagen(PICP) were significantly elevated. But IGFBP-3 were not shown to change significantly. The changes in serum levels of PICP during the first month of recombinant human GH treatment were positively related to growth velocity, whereas the changes in IGF-1 and OC during the first month of therapy were not. We conclude that the recombinant human GH treatment caused significant modifications of mineral metablism and that the measurement of the changes of biochemical markers of bone metablism espacially PICP may be a useful tool in prediction improved growth velocity during long term GH replacement therpy.

MeSH Terms

Biomarkers
Bone Remodeling*
Child*
Growth Hormone*
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Metabolism
Miners
Biomarkers
Growth Hormone
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I