Asia Pac Allergy.
2019 Oct;9(4):e33. 10.5415/apallergy.2019.9.e33.
The risk of preschool asthma at 2–4 years is not associated with leukocyte telomere length at birth or at 1 year of age
- Affiliations
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- 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
- 2Department of Pediatrics, Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul, Korea. sjhong@amc.seoul.kr
- 3Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 4Department of Pediatrics, CHA University Gangnam CHA Hospital, Seoul, Korea.
- 5Department of Pediatrics, Yonsei University Severance Children's Hospital, Seoul, Korea.
- 6Department of Pediatrics, Sungkyunkwan University Samsung Medical Center, Seoul, Korea.
- KMID: 2461105
- DOI: http://doi.org/10.5415/apallergy.2019.9.e33
Abstract
- BACKGROUND
Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative stress may mediate this relationship.
OBJECTIVE
We aimed to evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure to oxidative stress, in early life is associated with increased risk of asthma development during the preschool period.
METHODS
We assessed the follow-up clinical data of a subgroup from a birth cohort whose LTLs had been measured from cord-blood and 1-year peripheral-blood samples. We examined whether the LTLs would be associated with asthma development at the age of 2-4 years.
RESULTS
The data of 84 subjects were analyzed. LTLs were measured from the cord-blood and 1-year peripheral blood of 75 and 79 subjects, respectively. Among them, 14 subjects (16.7%) developed bronchial asthma between 2-4 years old. Prenatally stressed subjects had marginally increased odds of developing asthma (p = 0.097). There was no significant difference in the odds of preschool-asthma development between the groups with shorter and longer cord-blood LTLs (odds ratio [OR], 0.651; 95% confidence interval [CI], 0.184-2.306) or in the odds between the groups with shorter and longer 1-year peripheral-blood LTLs (OR, 0.448; 95% CI, 0.135-1.483). Finally, subjects with both higher prenatal stress and shorter LTLs did not have significantly higher odds of preschool-asthma development (for cord-blood: OR, 1.242; 95% CI, 0.353-4.368; for 1-year peripheral-blood: OR, 1.451; 95% CI, 0.428-4.919).
CONCLUSION
There was no significant association between early life LTLs and higher risk of bronchial-asthma development during the preschool years.
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