Korean J Physiol Pharmacol.  2019 Nov;23(6):449-458. 10.4196/kjpp.2019.23.6.449.

Long non-coding RNA T-cell leukemia/lymphoma 6 serves as a sponge for miR-21 modulating the cell proliferation of retinoblastoma through PTEN

  • 1Department of Science and Education, Changsha Hospital for Maternal & Child Health Care, Changsha 410007, Hunan, China. 411238793@qq.com, jiayinxy2006@126.com
  • 2Department of Orthopedics, Shaoyang County People's Hospital, Shaoyang 422100, Hunan, China.
  • 3Department of Ophthalmology, The First Affiliated Hospital of Human Normal University/Hunan Provincial People's Hospital, Changsha 410002, Hunan, China.
  • 4Health Management Center, Changsha Hospital for Maternal & Child Health Care, Changsha 410007, Hunan, China.


Retinoblastoma (Rb) is one of the most common eye malignancies occur in childhood. The crucial roles of non-coding RNAs, particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been widely reported in Rb progression. In the present study, we found the expression of lncRNA T-cell leukemia/lymphoma 6 (TCL6) was significantly downregulated in Rb tissues and cell lines. Knockdown of lncRNA TCL6 promoted cell proliferation while reduced cell apoptosis in Rb cells. Moreover, lncRNA TCL6 serves as a sponge for miR-21, a previously-reported oncogenic miRNA in Rb, by direct targeting to negatively regulated miR-21 expression, therefore modulating Rb proliferation through miR-21. TCL6 overexpression inhibited Rb cell proliferation while miR-21 overexpression exerted an opposing effect; the effect of TCL6 overexpression was partially attenuated by miR-21 overexpression. PTEN/PI3K/AKT signaling pathway was involved in lncRNA TCL6/miR-21 axis modulating Rb cell proliferation. Taken together, lncRNA TCL6 serves as a tumor suppressor by acting as a sponge for miR-21 to counteract miR-21-mediated PTEN repression.


Cell proliferation; miRNA 21; Phosphate and tension homology deleted on chromsome ten (PTEN); Retinoblastoma

MeSH Terms

Cell Line
Cell Proliferation*
Repression, Psychology
RNA, Long Noncoding*
RNA, Untranslated
RNA, Long Noncoding
RNA, Untranslated
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