Diabetes Metab J.  2019 Oct;43(5):607-614. 10.4093/dmj.2018.0159.

Progression to Gestational Diabetes Mellitus in Pregnant Women with One Abnormal Value in Repeated Oral Glucose Tolerance Tests

• Kang S
• Kim MH
• Kim MY
• Hong JS
• Kwak SH
• Choi SH
• Lim S
• Park KS
• Jang HC

• KMID: 2460954
• DOI: http://doi.org/10.4093/dmj.2018.0159

Abstract

BACKGROUND
Women with one abnormal value (OAV) in a 100 g oral glucose tolerance test (OGTT) during pregnancy are reported to have an increased risk of adverse pregnancy outcomes. However, there is limited data about whether women with OAV will progress to gestational diabetes mellitus (GDM) when the OGTT is repeated.
METHODS
To identify clinical and metabolic predictors for GDM in women with OAV, we conducted a retrospective study and identified women with OAV in the OGTT done at 24 to 30 weeks gestational age (GA) and repeated the second OGTT between 32 and 34 weeks of GA.
RESULTS
Among 137 women with OAV in the initial OGTT, 58 (42.3%) had normal, 40 (29.2%) had OAV and 39 (28.5%) had GDM in the second OGTT. Maternal age, prepregnancy body mass index, weight gain from prepregnancy to the second OGTT, GA at the time of the OGTT, and parity were similar among normal, OAV, and GDM groups. Plasma glucose levels in screening tests were different (151.8±15.7, 155.8±14.6, 162.5±20.3 mg/dL, P<0.05), but fasting, 1-, 2-, and 3-hour glucose levels in the initial OGTT were not. Compared to women with screen negative, women with untreated OAV had a higher frequency of macrosomia.
CONCLUSION
We demonstrated that women with OAV in the initial OGTT significantly progressed to GDM in the second OGTT. Clinical parameters predicting progression to GDM were not found. Repeating the OGTT in women with OAV in the initial test may be helpful to detect GDM progression.

Keyword

Diabetes, gestational; Glucose tolerance test; Pregnancy outcome

MeSH Terms

Blood Glucose
Body Mass Index
Diabetes, Gestational*
Fasting
Female
Gestational Age
Glucose
Glucose Tolerance Test*
Humans
Mass Screening
Maternal Age
Parity
Pregnancy
Pregnancy Outcome
Pregnant Women*
Retrospective Studies
Weight Gain
Glucose

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