Ann Pediatr Endocrinol Metab.  2019 Sep;24(3):158-163. 10.6065/apem.2019.24.3.158.

Arterial stiffness in young women with Turner syndrome using cardio-ankle vascular index

• Heo YJ
• Jung HW
• Lee YA
• Shin CH
• Yang SW

• KMID: 2460762
• DOI: http://doi.org/10.6065/apem.2019.24.3.158

Abstract

PURPOSE
Patients with Turner syndrome (TS) have increased risk of morbidities and mortality related to cardiovascular complications. Cardio-ankle vascular index (CAVI) is a novel method of evaluating arterial stiffness independent of changes in blood pressure. We compared arterial stiffness using CAVI between TS patients and healthy control subjects.
METHODS
Nineteen young women with TS (mean, 26.8 years; range, 20.0-35.1 years) and 23 healthy women matched for age and body mass index (BMI) were recruited for CAVI measurements at Seoul National University Hospital between 2010 and 2013. Anthropometric parameters, fasting blood testing and measurements of CAVI were compared between the 2 groups.
RESULTS
TS patients were significantly shorter (mean: 150.1 cm vs. 160.7 cm, P<0.001) and had lower body weight (mean: 47.0 kg vs. 55.5 kg, P=0.014) than healthy controls, without difference in BMI. CAVI (6.5±0.6 vs. 6.1±0.6, P=0.039) was significantly higher in TS patients compared to healthy controls. Age was positively associated with CAVI (r=0.403, P=0.008) in univariate analysis. After adjusting for age, TS was associated with CAVI (P=0.006).
CONCLUSION
Young women with TS showed increased arterial stiffness measured by CAVI compared to healthy women after adjusting for age, suggesting inherent vasculopathy in TS patients.

Keyword

Turner syndrome; Cardiovascular abnormalities; Vascular stiffness

MeSH Terms

Blood Pressure
Body Mass Index
Body Weight
Cardiovascular Abnormalities
Fasting
Female
Hematologic Tests
Humans
Methods
Mortality
Seoul
Turner Syndrome*
Vascular Stiffness*

Figure

• 

  Fig. 1. Comparison of CAVI between women with Turner syndrome and healthy control subjects. CAVI was significantly higher in women with Turner syndrome than in healthy control subjects. (6.5±0.6 vs. 6.1±0.6, P=0.039). CAVI, cardio-ankle vascular index.

Reference

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