A Comparison of the Chemistry of Blood from Bone Marrow and Peripheral Blood

Jahng, Jun Seop; Chung, In Hee

Abstract

The mineral salts deposited in the skeleton are not in chemical equilibrium with the circulating blood (Ramp and Neuman), and while the local concentration in bone lesions might thus be high, after dilution into the entire circulating volume, the total amount of enzyme might be too small to cause changes in the peripheral blood readings. And even when no tissue is obtained, the bone blood from the lesion may p ovide useful information (Woodard and Marcove); This study was undertaken to assess the clinical usefulness of bone marrow blood as an indicator of the early findings of bone tumor. Ten ml. of bone marrow blood was obtained from the iliac donor site at the time of bone grafting for spondylolysis, spondylolisthesis and lumbar disc herniation and 10 ml. of peripheral blood was obtained from the cephalic vein immediately before the bone grafting. And electrolyte composition of bone marrow blood was compared with peripheral blood. Electrolyte and enzyme composition of bone marrow blood from bone tumor sites was compared with peripheral blood and also with that obtained from the bone grafting (control) group. The results obtained are as follows.; 1. The concentration of total calcium in the bone marrow blood was significantly lower and inorganic phosphorus was significantly higher than values obtained from the peripheral blood of obtained from the bone grafting group. A moderate excess of alkaline phosphatase was found in the bone marrow blood. 2 A large excess of alkaline phosphatase was found in the bone marrow blood obtained from bone tumor.

A Comparison of the Chemistry of Blood from Bone Marrow and Peripheral Blood

Abstract

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