J Korean Ophthalmol Soc.  2019 Oct;60(10):929-934. 10.3341/jkos.2019.60.10.929.

Repeatability and Reproducibility of Tear Meniscus Evaluations Using Two Different Spectral Domain-optical Coherence Tomography

• Kim JH
• Choi KR
• Jun RM
• Han KE

• KMID: 2460510
• DOI: http://doi.org/10.3341/jkos.2019.60.10.929

Abstract

PURPOSE
To evaluate the repeatability and reproducibility of inferior tear meniscus measurements using two different spectral domain-optical coherence tomography (OCT), and to compare the inter-device agreements between these devices.
METHODS
Two examiners evaluated the tear meniscus depth (TMD) and tear meniscus height (TMH) of 20 eyes in 20 normal subjects using Cirrus OCT and Spectralis OCT with the examiners calculating the TMD and TMH. We analyzed intra-examiner repeatability, inter-examiner reproducibility, and inter-device agreement.
RESULTS
The average TMD measurements using the Cirrus OCT and Spectralis OCT devices were 151.25 ± 41.53 µm and 139.10 ± 40.56 µm by examiner 1, respectively, and 152.03 ± 42.77 µm and 138.35 ± 39.70 µm by examiner 2, respectively. The TMHs were 291.90 ± 100.19 µm and 245.43 ± 66.44 µm by examiner 1, respectively, and 288.25 ± 98.72 µm and 244.23 ± 60.69 µm by examiner 2, respectively. The TMDs and TMHs measured using these OCT devices were not statistically significant for intra-examiner and inter-examiner measurements (all, p > 0.05). These devices showed high repeatability (intraclass correlation coefficient ≥ 0.991) for intra-examiner TMD and TMH measurements and the inter-examiner coefficient of variation ranged from 2.04% to 4.32%. The 95% limits of agreement between the two devices were −66.13 to 91.95 µm for TMD and −127.18 to 217.68 µm for TMH.
CONCLUSIONS
Both OCT devices are useful for conducting inferior tear meniscus measurements. The inter-device agreement was poor, and the devices were not interchangeable.

Keyword

Cirrus optical coherence tomography; Spectralis optical coherence tomography; Tear meniscus depth; Tear meniscus height

MeSH Terms

Tears*

Figure

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  Figure 1 Tear meniscus depth (TMD) and tear meniscus height (TMH). Measurement of TMD and TMH in the Cirrus optical coherence tomography (OCT) (A) and Spectralis OCT (B).

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  Figure 2 Bland-Altman plots. Bland-Altman plots of the tear meniscus depth tear meniscus depth and tear meniscus height tear meniscus height difference between Cirrus optical coherence tomography (OCT) and Spectralis OCT. TMD = tear meniscus depth; TMH = tear meniscus height.

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