J Neurogastroenterol Motil.  2019 Oct;25(4):534-543. 10.5056/jnm19060.

Association Between Symptoms, Quality of Life, and Gastric Emptying in Dyspeptic Patients

Affiliations
  • 1Department of Gastroenterology and Hepatology, CHU UCL Namur, Godinne University Hospital, UCLouvain, Yvoir, Belgium.
  • 2Department of Physiology, Rouen University Hospital, Normandie University, Rouen, France. guillaume.gourcerol@chu-rouen.fr
  • 3Nutrition, Gut and Brain Laboratory (INSERM UMR 1073), Institute for Biomedical Research and innovation, Rouen University, Normandie University, Rouen, France.
  • 4Department of Gastroenterology, Rouen University Hospital, Normandie University, Rouen, France.
  • 5Department of Physiology, INSERM CIC-CRB 1404, Rouen University Hospital, INSERM Unit 1073, UNIROUEN, Normandie University, Rouen, France.

Abstract

BACKGROUND/AIMS
Association between symptoms, quality of life and gastric emptying in dyspepsia is inconsistent in the literature. The aim of our study is to investigate if gastric emptying is associated with specific symptoms and quality of life in dyspeptic patients.
METHODS
We reviewed retrospectively gastric emptying measured by ¹³C-labelled octanoate breath testing for more than 6 hours in 198 consecutive patients with dyspepsia complaints. Gastrointestinal symptoms were assessed using a 5-points Likert scale and by a symptomatic composite score, whereas quality of life was measured by the GIQLI.
RESULTS
In our cohort, 90 patients (45%) had a delayed gastric emptying (half emptying time above 166 minutes when assessed over 6-8 hours). There was no difference in symptoms or quality of life between patients with or without delayed gastric emptying. However, patients with severely delayed gastric emptying (half emptying time above 200 minutes) had increased postprandial fullness (P = 0.012), abdominal pain (P = 0.026), bloating (P = 0.044), early satiety (P = 0.018), symptomatic composite score (P = 0.005), and a lower quality of life (P = 0.018). This association was no longer observed if the calculation of gastric emptying was limited to the first 4-hour samples.
CONCLUSIONS
There is no association between symptoms, quality of life and gastric emptying in an overall dyspeptic population. However, there is an association between symptoms, quality of life of delayed gastric emptying in the subgroup of patients with severely delayed gastric emptying. An 8-hour measurement of gastric emptying should be recommended.

Keyword

Breath tests; Dyspepsia; Gastric emptying; Gastroparesis; Quality of life

MeSH Terms

Abdominal Pain
Breath Tests
Cohort Studies
Dyspepsia
Gastric Emptying*
Gastroparesis
Humans
Quality of Life*
Retrospective Studies
Full Text Links
  • JNM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error