Nat Prod Sci.  2019 Sep;25(3):233-237. 10.20307/nps.2019.25.3.233.

Diels-Alder Type Adducts from Hairy Root Cultures of Morus macroura

• Happyana N
• Hakim EH
• Syah YM
• Kayser O
• Juliawaty
• Mujahidin
• Ermayanti
• Achmad SA

• KMID: 2459965
• DOI: http://doi.org/10.20307/nps.2019.25.3.233

Abstract

Three Diels-Alder type adducts, guangsangon E (1), chalcomoracin (2) and sorocein I (3) were isolated from hairy root cultures of Morus macroura. The structures of the isolated compounds (1 - 3) were determined by spectroscopic method (NMR and MS), and spectral comparison to literature. Cytotoxic activities of the isolated compounds (1 - 3) were investigated against P-388 murine leukemia cell line. Guangsangon E (1) showed the most potent cytotoxicity against P-388 murine leukemia cell line with ICâ‚…â‚€ value of 2.75 ± 0.32 µg/mL. To the best of our knowledge, guangsangon E (1) and sorocein I (3) were reported for the first time from the tissue cultures of M. macroura.

Keyword

Diels-Alder type adduct; Morus macroura; tissue cultures; cytotoxicity

MeSH Terms

Cell Line
Inhibitory Concentration 50
Leukemia
Methods
Morus*

Figure

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  Fig. 1 Growth of hairy root cultures of M. macroura.

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  Fig. 2 The molecular structures of 1 – 3, isolated from hairy root cultures of M. macroura.

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