Nat Prod Sci.  2019 Sep;25(3):233-237. 10.20307/nps.2019.25.3.233.

Diels-Alder Type Adducts from Hairy Root Cultures of Morus macroura

Affiliations
  • 1Chemistry Study Program, Faculty of Mathematics and Natural Sciences, Bandung Institute of Technology, Jl. Ganesha 10, 40132 Bandung, Indonesia. nizar@chem.itb.ac.id
  • 2Department of Technical Biochemistry, Technical University of Dortmund, Emil-Figge-Str. 66, 44227 Dortmund, Germany.
  • 3Research Center of Biotechnology, Indonesian Institute of Sciences (LIPI), Jl. Raya Bogor KM. 46 Cibinong 16911, Indonesia.

Abstract

Three Diels-Alder type adducts, guangsangon E (1), chalcomoracin (2) and sorocein I (3) were isolated from hairy root cultures of Morus macroura. The structures of the isolated compounds (1 - 3) were determined by spectroscopic method (NMR and MS), and spectral comparison to literature. Cytotoxic activities of the isolated compounds (1 - 3) were investigated against P-388 murine leukemia cell line. Guangsangon E (1) showed the most potent cytotoxicity against P-388 murine leukemia cell line with ICâ‚…â‚€ value of 2.75 ± 0.32 µg/mL. To the best of our knowledge, guangsangon E (1) and sorocein I (3) were reported for the first time from the tissue cultures of M. macroura.

Keyword

Diels-Alder type adduct; Morus macroura; tissue cultures; cytotoxicity

MeSH Terms

Cell Line
Inhibitory Concentration 50
Leukemia
Methods
Morus*

Figure

  • Fig. 1 Growth of hairy root cultures of M. macroura.

  • Fig. 2 The molecular structures of 1 – 3, isolated from hairy root cultures of M. macroura.


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