J Obes Metab Syndr.  2019 Jun;28(2):118-128. 10.7570/jomes.2019.28.2.118.

Components of Metabolic Syndrome in Korean Adults: A Hospital-Based Cohort at Seoul National University Bundang Hospital

• Lim S
• Min SH
• Lee JH
• Kim LK
• Lee DH
• Lee JE
• Kim KM
• Lee S
• Park KC
• Lee YJ

• KMID: 2459824
• DOI: http://doi.org/10.7570/jomes.2019.28.2.118

Abstract

BACKGROUND
The prevalence of metabolic syndrome is increasing in Korea, particularly among young adults. This trend will increase the incidence of cardiovascular and metabolic diseases in the future. Therefore, it is imperative to detect and prevent metabolic abnormalities early in life. Here, we established a hospital-based biobank cohort to identify the most prevalent dysmetabolic phenotype. The aim of this report was to inform other researchers of our protocol and to share our data for future collaboration.
METHODS
The baseline examination comprised health-related questionnaires, anthropometric and handgrip strength measurements, bioelectrical impedance analysis of body composition, and nutritional assessment. Relevant biochemical parameters were measured, and oral glucose tolerance tests were performed. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria with Asian waist circumference criteria.
RESULTS
From a total of about 3,000 employees aged 20 to 59 years working at Seoul National University Bundang Hospital, 1,017 were enrolled from 2015 to 2016. The mean age was 34.5±8.4 years for men (n=311, 30.6%) and 30.9±8.5 years for women (n=706, 69.4%). The overall prevalence of metabolic syndrome was 7.6% (17.7% in men and 3.1% in women). Among the five components of metabolic syndrome, high blood pressure was the most prevalent in both men (51.4%) and women (13.8%).
CONCLUSION
Although further follow-up data are needed, we expect that more adverse cardiovascular events may occur in men than in women. This hospital-based cohort will serve as the foundation for a comprehensive evaluation of metabolic syndrome and future cardiometabolic disease risk in middle-aged Koreans.

Keyword

Metabolic syndrome; Cardiovascular disease; Risk factor; Biobank

MeSH Terms

Adult*
Asian Continental Ancestry Group
Body Composition
Cardiovascular Diseases
Cholesterol
Cohort Studies*
Cooperative Behavior
Education
Electric Impedance
Female
Follow-Up Studies
Glucose Tolerance Test
Humans
Hypertension
Incidence
Korea
Male
Metabolic Diseases
Nutrition Assessment
Phenotype
Prevalence
Risk Factors
Seoul*
Waist Circumference
Young Adult
Cholesterol