Korean J Dermatol.  2019 Aug;57(7):391-394.

Clinco-pathologic Features of Alopecia in a Patient of Cronkhite-Canada Syndrome

• Seong GH
• Shon U
• Park MJ
• Park M
• Hong SP
• Kim MH
• Park BC

Abstract

Although hair loss in Cronkhite-Canada syndrome (CCS) developed frequently, its exact mechanism has not been elucidated. Thus, we attempted to investigate the histopathologic features of hair loss with scalp biopsy in one case of CSS. The patient complained of persistent diarrhea and diffuse hair loss of the scalp 1 month prior to the hospital visit. CCS has been already diagnosed through colonoscopy and medical examination. Scalp biopsy was performed to evaluate hair loss of the patient, and pathologic examination showed increased telogen hairs (anagen to telogen is 7:8) without specific dermal inflammation and miniaturization of hair follicles. The patient was treated with topical and systemic steroids, and hair loss has almost completely recovered in 5 months. In this case, we investigated the clinical and pathological features of hair loss through scalp biopsy in one case of CCS and reported them with a review of the literature.

Keyword

Abdominal discomfort; Cronkhite-Canada syndrome; Diffuse alopecia; Ectodermal changes

MeSH Terms

Alopecia*
Biopsy
Colonoscopy
Diarrhea
Hair
Hair Follicle
Humans
Inflammation
Intestinal Polyposis*
Miniaturization
Scalp
Steroids
Steroids