Korean J Helicobacter Up Gastrointest Res.  2019 Jun;19(2):99-105. 10.7704/kjhugr.2019.19.2.99.

The Role of Gut Microbiota and Use of Probiotics in the Treatment of Upper Gastrointestinal Diseases

• Lee MY
• Choi SC
• Kim YS

• KMID: 2457623
• DOI: http://doi.org/10.7704/kjhugr.2019.19.2.99

Abstract

Gut microbiota have been known to play an essential role in host immunity and metabolism. Dysbiosis is associated with various gastrointestinal (GI) and other diseases such as cancers, metabolic diseases, allergies, and immunological disorders. So far, the role of gut microbiota has been studied mainly in lower GI disease but has recently been reported in upper GI diseases other than Helicobacter pylori infection, including Barrett's esophagus, esophageal carcinoma, gastric cancer, functional dyspepsia, and non-steroidal anti-inflammatory drug-induced small intestinal mucosal injury. Probiotics have some beneficial effect on these diseases, but the effects are strain specific.

Keyword

Anti-inflammatory agents, non-steroidal; Helicobacter infections; Microbiota; Probiotics; Upper gastrointestinal tract

MeSH Terms

Anti-Inflammatory Agents, Non-Steroidal
Barrett Esophagus
Dysbiosis
Dyspepsia
Gastrointestinal Diseases*
Gastrointestinal Microbiome*
Helicobacter Infections
Helicobacter pylori
Hypersensitivity
Metabolic Diseases
Metabolism
Microbiota
Probiotics*
Stomach Neoplasms
Upper Gastrointestinal Tract
Anti-Inflammatory Agents, Non-Steroidal