Ann Lab Med.  2020 Jan;40(1):80-83. 10.3343/alm.2020.40.1.80.

The First Korean Case of Epstein-Barr Virus-positive Natural Killer/T-cell Lymphoma That Progressed From Severe Mosquito Bite Allergy, With Coexistence of Hemophagocytic Lymphohistiocytosis

• Lee S
• Park CJ
• Cho YU
• Jang S
• Huh J
• Kim H

• KMID: 2457499
• DOI: http://doi.org/10.3343/alm.2020.40.1.80

Abstract

No abstract available.

MeSH Terms

Culicidae*
Hypersensitivity*
Lymphohistiocytosis, Hemophagocytic*
Lymphoma*

Figure

• 

  Fig. 1 BM findings of NK/T-cell lymphoma in this patient. Arrows on each figure indicate neoplastic lymphocytes. (A) Neoplastic lymphocytes with medium size, round or slightly irregular nuclei, indistinct nucleoli, and slightly basophilic cytoplasm containing some granules and cytoplasmic vacuoles (BM aspirate, Wright stain, ×1,000). (B) Interstitial infiltration of neoplastic lymphocytes (BM biopsy, H & E stain, ×1,000). (C) Increased neoplastic CD8+ T cells (BM biopsy, CD3 IHC, ×400). (D) Increased neoplastic CD56+ NK cells (BM biopsy, CD56 IHC, ×400). (E) Increased EBV-positive neoplastic lymphocytes (BM biopsy, EBV in situ hybridization, ×400). (F) Markedly decreased CD4+ T cells (BM biopsy, CD4 IHC, ×400). Abbreviations: BM, bone marrow; NK, natural killer; H&E, hematoxylin and eosin; EBV, Epstein-Barr virus; IHC, immunohistochemistry.

• 

  Fig. 2 TCR gene rearrangement using BM aspirates: clonal peaks for rearranged TCRγ gene. Abbreviations: TCR, T-cell receptor; BM, bone marrow.

Reference

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